Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial

There is an emerging realization from animal models that the immune response may have both detrimental and beneficial therapeutic effects during cancer virotherapy. However, there is a dearth of clinical data on the immune response to viral agents in patients. During a recently completed phase I tri...

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Veröffentlicht in:	Gene therapy 2008-06, Vol.15 (12), p.911-920
Hauptverfasser:	White, C L, Twigger, K R, Vidal, L, De Bono, J S, Coffey, M, Heinemann, L, Morgan, R, Merrick, A, Errington, F, Vile, R G, Melcher, A A, Pandha, H S, Harrington, K J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animal models Antibodies, Viral - blood Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cancer Care and treatment CD25 antigen CD3 antigen CD4 antigen CD56 antigen CD8 antigen Cell activation Cell Biology Cell culture Cytokines Cytokines - blood Cytotoxicity Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic Therapy - methods Health. Pharmaceutical industry Human Genetics Humans Immunity, Innate Immunology Immunotherapy Industrial applications and implications. Economical aspects Injections, Intravenous Innate immunity Intravenous administration Leukocytes (mononuclear) Lymphocyte Count Lymphocytes T Male Mammalian orthoreovirus 3 - immunology Medical sciences Middle Aged Nanotechnology Neoplasms - immunology Neoplasms - therapy Oncology Oncolysis Oncolytic Virotherapy - methods original-article Patients Perforin Peripheral blood mononuclear cells Reovirus T-Lymphocyte Subsets - immunology Tissue culture Transfusions. Complications. Transfusion reactions. Cell and gene therapy Treatment Outcome Tumors Viruses
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