Age-at-onset and schizophrenia: reversed gender effect
Objective: This study seeks an explanation for reversed gender effect on age‐at‐onset (AAO) in schizophrenia. The hypothesis is older AAO in males would be detected in a sample where higher infant mortality (IMR) prevailed. Method: Case records of International Classification of Diseases‐10 (ICD‐10)...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2002-04, Vol.105 (4), p.317-319 |
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| container_title | Acta psychiatrica Scandinavica |
| container_volume | 105 |
| creator | Gangadhar, B. N. Panner Selvan, C. Subbakrishna, D. K. Janakiramaiah, N. |
| description | Objective: This study seeks an explanation for reversed gender effect on age‐at‐onset (AAO) in schizophrenia. The hypothesis is older AAO in males would be detected in a sample where higher infant mortality (IMR) prevailed.
Method: Case records of International Classification of Diseases‐10 (ICD‐10) schizophrenia patients from two states (n=70 each) with an IMR of 13 and 67 per thousand were reviewed and AAO was obtained by using the recorded age and duration of illness.
Results: In the sample from the state with lower IMR, AAO did not differ between the two sexes. However, men had older AAO than women in the state with fivefold higher IMR.
Conclusion: Gender differences in AAO may be a function of perinatal complications. In places where infants with perinatal complications are less likely to survive, hence high IMR, a small group of potentially youngest AAO schizophrenic males may be eliminated thus changing the gender effect on AAO. |
| doi_str_mv | 10.1034/j.1600-0447.2002.1153.x |
| format | Article |
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Method: Case records of International Classification of Diseases‐10 (ICD‐10) schizophrenia patients from two states (n=70 each) with an IMR of 13 and 67 per thousand were reviewed and AAO was obtained by using the recorded age and duration of illness.
Results: In the sample from the state with lower IMR, AAO did not differ between the two sexes. However, men had older AAO than women in the state with fivefold higher IMR.
Conclusion: Gender differences in AAO may be a function of perinatal complications. In places where infants with perinatal complications are less likely to survive, hence high IMR, a small group of potentially youngest AAO schizophrenic males may be eliminated thus changing the gender effect on AAO.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1034/j.1600-0447.2002.1153.x</identifier><identifier>PMID: 11942937</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford UK: Blackwell Publishers</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age Distribution ; Age of Onset ; Biological and medical sciences ; Female ; Humans ; India - epidemiology ; Lancashire Quality of Life Profile ; Male ; Medical sciences ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; quality of life ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - epidemiology ; Sex Distribution ; SF-36 ; Tropical medicine</subject><ispartof>Acta psychiatrica Scandinavica, 2002-04, Vol.105 (4), p.317-319</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4313-e31aa633a4ecdc67ea3e1b5e152dc8f14c9bcbaea891110f21001ec7cb10be733</citedby><cites>FETCH-LOGICAL-c4313-e31aa633a4ecdc67ea3e1b5e152dc8f14c9bcbaea891110f21001ec7cb10be733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0447.2002.1153.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0447.2002.1153.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13573288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11942937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gangadhar, B. N.</creatorcontrib><creatorcontrib>Panner Selvan, C.</creatorcontrib><creatorcontrib>Subbakrishna, D. K.</creatorcontrib><creatorcontrib>Janakiramaiah, N.</creatorcontrib><title>Age-at-onset and schizophrenia: reversed gender effect</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective: This study seeks an explanation for reversed gender effect on age‐at‐onset (AAO) in schizophrenia. The hypothesis is older AAO in males would be detected in a sample where higher infant mortality (IMR) prevailed.
Method: Case records of International Classification of Diseases‐10 (ICD‐10) schizophrenia patients from two states (n=70 each) with an IMR of 13 and 67 per thousand were reviewed and AAO was obtained by using the recorded age and duration of illness.
Results: In the sample from the state with lower IMR, AAO did not differ between the two sexes. However, men had older AAO than women in the state with fivefold higher IMR.
Conclusion: Gender differences in AAO may be a function of perinatal complications. In places where infants with perinatal complications are less likely to survive, hence high IMR, a small group of potentially youngest AAO schizophrenic males may be eliminated thus changing the gender effect on AAO.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age Distribution</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Lancashire Quality of Life Profile</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>quality of life</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - epidemiology</subject><subject>Sex Distribution</subject><subject>SF-36</subject><subject>Tropical medicine</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFtPgzAYQBujcfPyF5QXfSv2o0DBxIdl6nQaL1Gjb00pH5PJYLZMp79eyIi--tRLzunXHEL2gbnAuH80dSFkjDLfF67HmOcCBNxdrpH-7_066TPGgIYxe-mRLWunzTEAFm2SHkDsezEXfRIOJkhVTavSYu2oMnWsfs2_q_mrwTJXx47BDzQWU2eCZYrGwSxDXe-QjUwVFne7dZs8nZ89Di_o9e3ocji4ptrnwClyUCrkXPmoUx0KVBwhCRACL9VRBr6OE50oVFEMACzzoPkxaqETYAkKzrfJ4erduaneF2hrOcutxqJQJVYLKwWEngAfGlCsQG0qaw1mcm7ymTJfEphsk8mpbNPINo1sk8k2mVw25l43YpHMMP3zukYNcNABympVZEaVOrd_HA8E96Ko4U5W3Gde4Nd_58vB8O6h3TY-Xfm5rXH56yvzJkPBRSCfb0ZyfD--Gj_fnMqI_wCjwJW2</recordid><startdate>200204</startdate><enddate>200204</enddate><creator>Gangadhar, B. N.</creator><creator>Panner Selvan, C.</creator><creator>Subbakrishna, D. K.</creator><creator>Janakiramaiah, N.</creator><general>Blackwell Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200204</creationdate><title>Age-at-onset and schizophrenia: reversed gender effect</title><author>Gangadhar, B. N. ; Panner Selvan, C. ; Subbakrishna, D. K. ; Janakiramaiah, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4313-e31aa633a4ecdc67ea3e1b5e152dc8f14c9bcbaea891110f21001ec7cb10be733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age Distribution</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Lancashire Quality of Life Profile</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>quality of life</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - epidemiology</topic><topic>Sex Distribution</topic><topic>SF-36</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gangadhar, B. N.</creatorcontrib><creatorcontrib>Panner Selvan, C.</creatorcontrib><creatorcontrib>Subbakrishna, D. K.</creatorcontrib><creatorcontrib>Janakiramaiah, N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gangadhar, B. N.</au><au>Panner Selvan, C.</au><au>Subbakrishna, D. K.</au><au>Janakiramaiah, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-at-onset and schizophrenia: reversed gender effect</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2002-04</date><risdate>2002</risdate><volume>105</volume><issue>4</issue><spage>317</spage><epage>319</epage><pages>317-319</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Objective: This study seeks an explanation for reversed gender effect on age‐at‐onset (AAO) in schizophrenia. The hypothesis is older AAO in males would be detected in a sample where higher infant mortality (IMR) prevailed.
Method: Case records of International Classification of Diseases‐10 (ICD‐10) schizophrenia patients from two states (n=70 each) with an IMR of 13 and 67 per thousand were reviewed and AAO was obtained by using the recorded age and duration of illness.
Results: In the sample from the state with lower IMR, AAO did not differ between the two sexes. However, men had older AAO than women in the state with fivefold higher IMR.
Conclusion: Gender differences in AAO may be a function of perinatal complications. In places where infants with perinatal complications are less likely to survive, hence high IMR, a small group of potentially youngest AAO schizophrenic males may be eliminated thus changing the gender effect on AAO.</abstract><cop>Oxford UK</cop><pub>Blackwell Publishers</pub><pmid>11942937</pmid><doi>10.1034/j.1600-0447.2002.1153.x</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Adult and adolescent clinical studies Age Distribution Age of Onset Biological and medical sciences Female Humans India - epidemiology Lancashire Quality of Life Profile Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses quality of life Schizophrenia Schizophrenia - diagnosis Schizophrenia - epidemiology Sex Distribution SF-36 Tropical medicine |
| title | Age-at-onset and schizophrenia: reversed gender effect |
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