Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes

Aims/hypothesis In patients with type 2 diabetes, reduced levels of circulating endothelial progenitor cells have been reported and these have been correlated with disease severity. In this study, we examined a panel of markers widely used to identify progenitor and/or stem cells, and determined the...

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Veröffentlicht in:	Diabetologia 2008-07, Vol.51 (7), p.1296-1305
Hauptverfasser:	Egan, C. G, Lavery, R, Caporali, F, Fondelli, C, Laghi-Pasini, F, Dotta, F, Sorrentino, V
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Antigens, CD - metabolism Antigens, CD34 - metabolism Biological and medical sciences Biomarkers - metabolism Bone marrow Cardiovascular disease Chemokine (C-X-C motif) receptor 4 Chemokines Chronic illnesses CXCR4 Diabetes Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - pathology Diabetes. Impaired glucose tolerance Diabetic Angiopathies - immunology Diabetic Angiopathies - pathology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelial Cells - cytology Endothelial progenitor cells EPC Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Flow Cytometry Glycoproteins - metabolism Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Human Physiology Humans Internal Medicine Kinases Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Microvascular disease Middle Aged mononuclear leukocytes noninsulin-dependent diabetes mellitus PBMCs Peptides - metabolism Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Proto-Oncogene Proteins c-kit - metabolism Receptors, CXCR4 - immunology Receptors, CXCR4 - metabolism Severity of Illness Index Stem cells Surface marker Vascular Endothelial Growth Factor Receptor-2 - metabolism
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