Synthesis of lidocaine-loaded PLGA microparticles by flow focusing Effects on drug loading and release properties

In the present work, two methods for the preparation of lidocaine-loaded PLGA microparticles are compared. The differences between the polymeric particles obtained by solvent evaporation (SEVM) or flow focusing (FF) were studied by means of scanning electron microscopy and surface thermodynamics det...

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Veröffentlicht in:	International journal of pharmaceutics 2008-06, Vol.358 (1-2), p.27-35
Hauptverfasser:	HOLGADO, M. A, ARIAS, J. L, COZAR, M. J, ALVAREZ-FUENTES, J, GANAN-CALVO, A. M, FERNANDEZ-AREVALO, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anesthetics, Local - administration & dosage Anesthetics, Local - chemical synthesis Biological and medical sciences Calorimetry, Differential Scanning Chemistry, Pharmaceutical Drug Compounding General pharmacology Lactic Acid Lidocaine - administration & dosage Lidocaine - chemical synthesis Medical sciences Microscopy, Electron, Scanning Nanoparticles Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyglycolic Acid Solubility Thermodynamics
Online-Zugang:	Volltext
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