Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation
Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (viment...
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| Veröffentlicht in: | International journal of gynecological cancer 2002-03, Vol.12 (2), p.223-227 |
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| container_title | International journal of gynecological cancer |
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| creator | Ribeiro-Silva, A Novello-Vilar, A Cunha-Mercante, A. M De Angelo Andrade, L. A. L |
| description | Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (vimentin positive) with heterologous (myoblastic) differentiation (focal 1A4 positive). There were also cells with neuroendocrine features that expressed S-100 and chromogranin A. Along with a brief review of this amazing neoplasm, some histogenetic concepts relevant to this case are discussed. To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation. |
| doi_str_mv | 10.1136/ijgc-00009577-200203000-00016 |
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To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.</description><identifier>ISSN: 1048-891X</identifier><identifier>EISSN: 1525-1438</identifier><identifier>DOI: 10.1136/ijgc-00009577-200203000-00016</identifier><identifier>PMID: 11975686</identifier><language>eng</language><publisher>England: Elsevier Limited</publisher><subject>Aged ; Carcinoma, Neuroendocrine - diagnosis ; Carcinoma, Neuroendocrine - pathology ; Carcinoma, Neuroendocrine - therapy ; Cervix ; Chemotherapy, Adjuvant ; Female ; Humans ; Hysterectomy ; Immunohistochemistry ; Mixed Tumor, Malignant - diagnosis ; Mixed Tumor, Malignant - pathology ; Mixed Tumor, Malignant - therapy ; Mixed Tumor, Mullerian - diagnosis ; Mixed Tumor, Mullerian - pathology ; Mixed Tumor, Mullerian - therapy ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - therapy</subject><ispartof>International journal of gynecological cancer, 2002-03, Vol.12 (2), p.223-227</ispartof><rights>2002 IGCS</rights><rights>2002 2002 IGCS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b1856-817b49a9c4105363661af9b13dbefa9d3c8022505352511065b992dd880d81333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11975686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro-Silva, A</creatorcontrib><creatorcontrib>Novello-Vilar, A</creatorcontrib><creatorcontrib>Cunha-Mercante, A. M</creatorcontrib><creatorcontrib>De Angelo Andrade, L. A. L</creatorcontrib><title>Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation</title><title>International journal of gynecological cancer</title><addtitle>Int J Gynecol Cancer</addtitle><description>Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (vimentin positive) with heterologous (myoblastic) differentiation (focal 1A4 positive). There were also cells with neuroendocrine features that expressed S-100 and chromogranin A. Along with a brief review of this amazing neoplasm, some histogenetic concepts relevant to this case are discussed. To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.</description><subject>Aged</subject><subject>Carcinoma, Neuroendocrine - diagnosis</subject><subject>Carcinoma, Neuroendocrine - pathology</subject><subject>Carcinoma, Neuroendocrine - therapy</subject><subject>Cervix</subject><subject>Chemotherapy, Adjuvant</subject><subject>Female</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Immunohistochemistry</subject><subject>Mixed Tumor, Malignant - diagnosis</subject><subject>Mixed Tumor, Malignant - pathology</subject><subject>Mixed Tumor, Malignant - therapy</subject><subject>Mixed Tumor, Mullerian - diagnosis</subject><subject>Mixed Tumor, Mullerian - pathology</subject><subject>Mixed Tumor, Mullerian - therapy</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - therapy</subject><issn>1048-891X</issn><issn>1525-1438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqVkUFPHCEUx4mp6a62X8GQmHqbyoOBgYOHxqhtovFik_ZEmIFRNjOwMjPWfnuZ3bUm3srlwXu__-PBH6EvQL4CMHHqV_dNQfJSvKoKSgglLJ_mFIg9tAROeQElkx_ynpSykAp-LdDBMKxmESXqI1oAqIoLKZbo943p_H0wYcS9f3YW30xd55I3AY9THxOOLR4fHJ7GnAwONy49-Wf8x48POLgpRRdsbDYl69vWJRdGb0Yfwye035pucJ938RD9vLy4O_9eXN9e_Tj_dl3UILkoJFR1qYxqSiCcCSYEmFbVwGztWqMsayShlOdafhgAEbxWilorJbESGGOH6GTbd53i4-SGUfd-aFzXmeDiNOgKBC2ragaP34GrOKWQZ9OUc1oprgjN1NmWalIchuRavU6-N-mvBqJnB_TsgH51QP9zQG8cyPqj3S1T3Tv7pt59eQbkFqj71X_2fgEaUZJC</recordid><startdate>200203</startdate><enddate>200203</enddate><creator>Ribeiro-Silva, A</creator><creator>Novello-Vilar, A</creator><creator>Cunha-Mercante, A. 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L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1856-817b49a9c4105363661af9b13dbefa9d3c8022505352511065b992dd880d81333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Carcinoma, Neuroendocrine - diagnosis</topic><topic>Carcinoma, Neuroendocrine - pathology</topic><topic>Carcinoma, Neuroendocrine - therapy</topic><topic>Cervix</topic><topic>Chemotherapy, Adjuvant</topic><topic>Female</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Immunohistochemistry</topic><topic>Mixed Tumor, Malignant - diagnosis</topic><topic>Mixed Tumor, Malignant - pathology</topic><topic>Mixed Tumor, Malignant - therapy</topic><topic>Mixed Tumor, Mullerian - diagnosis</topic><topic>Mixed Tumor, Mullerian - pathology</topic><topic>Mixed Tumor, Mullerian - therapy</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribeiro-Silva, A</creatorcontrib><creatorcontrib>Novello-Vilar, A</creatorcontrib><creatorcontrib>Cunha-Mercante, A. 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M</au><au>De Angelo Andrade, L. A. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation</atitle><jtitle>International journal of gynecological cancer</jtitle><addtitle>Int J Gynecol Cancer</addtitle><date>2002-03</date><risdate>2002</risdate><volume>12</volume><issue>2</issue><spage>223</spage><epage>227</epage><pages>223-227</pages><issn>1048-891X</issn><eissn>1525-1438</eissn><abstract>Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (vimentin positive) with heterologous (myoblastic) differentiation (focal 1A4 positive). There were also cells with neuroendocrine features that expressed S-100 and chromogranin A. 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| subjects | Aged Carcinoma, Neuroendocrine - diagnosis Carcinoma, Neuroendocrine - pathology Carcinoma, Neuroendocrine - therapy Cervix Chemotherapy, Adjuvant Female Humans Hysterectomy Immunohistochemistry Mixed Tumor, Malignant - diagnosis Mixed Tumor, Malignant - pathology Mixed Tumor, Malignant - therapy Mixed Tumor, Mullerian - diagnosis Mixed Tumor, Mullerian - pathology Mixed Tumor, Mullerian - therapy Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - therapy |
| title | Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation |
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