Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2

Summary The 1p36 region of the human genome has been identified as containing a QTL for BMD in multiple studies. We analysed the TNFRSF1B gene from this region, which encodes the TNF receptor 2, in two large population-based cohorts. Our results suggest that variation in TNFRSF1B is associated with...

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Veröffentlicht in:	Osteoporosis international 2008-07, Vol.19 (7), p.961-968
Hauptverfasser:	Mullin, B. H., Prince, R. L., Dick, I. M., Islam, F. M. A., Hart, D. J., Spector, T. D., Devine, A., Dudbridge, F., Wilson, S. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Amino Acids - blood Australia - epidemiology Biological and medical sciences Bone density Bone Density - genetics Cohort Studies Diseases of the osteoarticular system Endocrinology Female Fractures, Bone - epidemiology Fractures, Bone - genetics Genotype Genotype & phenotype Humans Injuries of the limb. Injuries of the spine Investigative techniques, diagnostic techniques (general aspects) Medical sciences Medicine Medicine & Public Health Middle Aged Older people Original Article Orthopedics Osteoarticular system. Muscles Osteocalcin - blood Osteoporosis Osteoporosis, Postmenopausal - blood Osteoporosis, Postmenopausal - genetics Osteoporosis, Postmenopausal - urine Osteoporosis. Osteomalacia. Paget disease Polymorphism Polymorphism, Single Nucleotide Prevalence Radiodiagnosis. Nmr imagery. Nmr spectrometry Receptors, Tumor Necrosis Factor, Type II - genetics Rheumatology Traumas. Diseases due to physical agents United Kingdom - epidemiology Women
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