Increased Expression of Dihydrodiol Dehydrogenase Induces Resistance to Cisplatin in Human Ovarian Carcinoma Cells

We employed cDNA microarrays to identify the differentially expressed genes in a cisplatin-sensitive parental (2008) human ovarian carcinoma cell line and its cisplatin-resistant variant (2008/C13*). Differential expression of five genes was found in the 2008/C13* cells, a result confirmed by semi-q...

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Veröffentlicht in:	The Journal of biological chemistry 2002-04, Vol.277 (17), p.15035-15043
Hauptverfasser:	Deng, Hong Bing, Parekh, Hemant K., Chow, K.-C., Simpkins, Henry
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology apolipoprotein J cDNA microarrays Cisplatin - pharmacology dihydrodiol dehydrogenase DNA, Complementary Drug Resistance, Neoplasm Female glucose-6-phosphate dehydrogenase Humans Oligonucleotide Array Sequence Analysis ovarian carcinoma Ovarian Neoplasms - pathology Oxidoreductases - metabolism Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured
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