Importance of mast cells in the pathophysiology of asthma
MCs promote chronic inflammation and the development of airway remodeling in asthma through MC-derived cytokines, chemokines, proteases, and interaction with other immune cells (T cells and eosinophils). The rapid innovation of genetic technologies and new techniques of MC knock-out/knock-in animal...
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| Veröffentlicht in: | Clinical reviews in allergy & immunology 2002-04, Vol.22 (2), p.161-174 |
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| container_end_page | 174 |
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| container_title | Clinical reviews in allergy & immunology |
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| creator | Cho, Seong H Anderson, Andrea J Oh, Chad K |
| description | MCs promote chronic inflammation and the development of airway remodeling in asthma through MC-derived cytokines, chemokines, proteases, and interaction with other immune cells (T cells and eosinophils). The rapid innovation of genetic technologies and new techniques of MC knock-out/knock-in animal model are improving our understanding of the complex relationships between the various cell types involved in the immune network of the airway and will clarify the role of MCs in the pathogenesis of asthma. Targeting MCs may be a new treatment modality in treatment and prevention of asthma.[PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1385/CRIAI:22:2:161 |
| format | Article |
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Targeting MCs may be a new treatment modality in treatment and prevention of asthma.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 1080-0549</identifier><identifier>EISSN: 1080-0549</identifier><identifier>EISSN: 1559-0267</identifier><identifier>DOI: 10.1385/CRIAI:22:2:161</identifier><identifier>PMID: 11975421</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Asthma ; Asthma - immunology ; Asthma - physiopathology ; Humans ; Immunology ; Inflammation Mediators - physiology ; Mast Cells - physiology ; Medical research</subject><ispartof>Clinical reviews in allergy & immunology, 2002-04, Vol.22 (2), p.161-174</ispartof><rights>Humana Press Inc. 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-264eca4ad7937d6b12d7092bd2cd7d7969b11fa9da8268888881e3808f69a8f63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11975421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Seong H</creatorcontrib><creatorcontrib>Anderson, Andrea J</creatorcontrib><creatorcontrib>Oh, Chad K</creatorcontrib><title>Importance of mast cells in the pathophysiology of asthma</title><title>Clinical reviews in allergy & immunology</title><addtitle>Clin Rev Allergy Immunol</addtitle><description>MCs promote chronic inflammation and the development of airway remodeling in asthma through MC-derived cytokines, chemokines, proteases, and interaction with other immune cells (T cells and eosinophils). 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| fulltext | fulltext |
| identifier | ISSN: 1080-0549 |
| ispartof | Clinical reviews in allergy & immunology, 2002-04, Vol.22 (2), p.161-174 |
| issn | 1080-0549 1080-0549 1559-0267 |
| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Animals Asthma Asthma - immunology Asthma - physiopathology Humans Immunology Inflammation Mediators - physiology Mast Cells - physiology Medical research |
| title | Importance of mast cells in the pathophysiology of asthma |
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