The Impact of Molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly l-Lysine Dendrimers

The impact of PEGylation on the pharmacokinetics and biodistribution of 3H-labeled poly l-lysine dendrimers has been investigated after intravenous administration to rats. The volumes of distribution, clearance and consequently the plasma half-lives of the PEGylated dendrimers were markedly dependen...

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Veröffentlicht in:	Molecular pharmaceutics 2008-05, Vol.5 (3), p.449-463
Hauptverfasser:	Kaminskas, Lisa M, Boyd, Ben J, Karellas, Peter, Krippner, Guy Y, Lessene, Romina, Kelly, Brian, Porter, Christopher J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Availability Dendrimers - administration & dosage Dendrimers - chemical synthesis Dendrimers - pharmacokinetics Drug Delivery Systems - methods Half-Life Injections, Intravenous Male Metabolic Clearance Rate Molecular Structure Molecular Weight Polyethylene Glycols - pharmacokinetics Polylysine - administration & dosage Polylysine - blood Polylysine - pharmacokinetics Polylysine - urine Rats Rats, Sprague-Dawley Tissue Distribution Tritium
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