Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population

CD30-CD30 ligand (CD30L) signal transduction appears to protect against autoimmune diabetes by preventing expansion of autoreactive T cells and suppressing Th1-cytokine response. The purpose of this study was to determine whether CD30 or CD30L genes serve as a novel susceptibility gene for type 1 di...

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Veröffentlicht in:	Genes and immunity 2002-04, Vol.3 (2), p.96-101
Hauptverfasser:	Ahmed, S, Ihara, K, Bassuny, W M, Kuromaru, R, Kohno, H, Miyako, K, Matsuura, N, Iwata, I, Nagafuchi, S, Hara, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alleles Autoimmune diseases Biomedical and Life Sciences Biomedicine Cancer Research CD30 antigen CD30 Ligand Child Child, Preschool Chromosomes Cytokines Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Female Females full-paper Gene Expression Gene Frequency Gene polymorphism Genes Genetic Predisposition to Disease Genotype Human Genetics Humans Immunology Infant Infant, Newborn Japan Ki-1 Antigen - genetics Ligands Linkage Disequilibrium Lymphocytes Lymphocytes T Male Membrane Glycoproteins - genetics Pathogenesis Pediatrics Polymorphism Polymorphism, Genetic Promoter Regions, Genetic Sequence analysis Signal transduction Transcription
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