Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer

Summary Background and purpose Telomere function and DNA damage response pathways are frequently inactivated in cancer. Moreover, some telomere-binding proteins have been implicated in DNA repair. The purpose of this work consists of evaluating the prognostic impact of telomere dysfunction and its r...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2008-06, Vol.60 (3), p.416-425
Hauptverfasser:	Frías, Cristina, García-Aranda, Cristina, De Juan, Carmen, Morán, Alberto, Ortega, Paloma, Gómez, Ana, Hernando, Florentino, López-Asenjo, Jose-Antonio, Torres, Antonio-José, Benito, Manuel, Iniesta, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Cell Cycle Proteins - genetics Clinical outcome DNA Repair DNA Repair Enzymes - genetics DNA repair factors DNA-Binding Proteins Endonucleases Female Hematology, Oncology and Palliative Medicine Humans Lung Neoplasms - diagnosis Lung Neoplasms - enzymology Lung Neoplasms - genetics Male Medical sciences Middle Aged MutL Protein Homolog 1 N-Glycosyl Hydrolases - genetics Non-small cell lung cancer Nuclear Proteins - genetics Phosphoproteins - genetics Pneumology Poly(ADP-ribose) Polymerases - genetics Prognosis Pulmonary/Respiratory Telomerase - genetics Telomerase activity Telomere - enzymology Telomere - genetics Telomere function Telomere shortening Telomere-binding proteins Telomeric Repeat Binding Protein 2 - genetics Transcription Factor TFIIH Transcription Factors, TFII - genetics Tumors Tumors of the respiratory system and mediastinum
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