Cytokines of the Placenta and Extra-placental Membranes: Biosynthesis, Secretion and Roles in Establishment of Pregnancy in Women
Virtually all known cytokines have been demonstrated to be expressed in the placenta and associated fetal and maternal membranes during normal gestation. In addition to playing their traditional roles as modulators of immunological function, cytokines derived from the placenta and extraplacental mem...
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| Veröffentlicht in: | Placenta (Eastbourne) 2002-04, Vol.23 (4), p.239-256 |
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| creator | Bowen, J.M. Chamley, L. Mitchell, M.D. Keelan, J.A. |
| description | Virtually all known cytokines have been demonstrated to be expressed in the placenta and associated fetal and maternal membranes during normal gestation. In addition to playing their traditional roles as modulators of immunological function, cytokines derived from the placenta and extraplacental membranes, together with other locally-derived growth factors, appear to be implicated in various aspects of implantation and placental development. Imbalances in the intrauterine cytokine milieu around the time of implantation and invasion may play a causative role in disorders associated with early pregnancy failure, and are also associated with the abnormal trophoblast development seen in gestational trophoblastic disease. Cytokines thus appear to be an important component of a paracrine/autocrine communication network operating within the feto-maternal interface to ensure the successful establishment of pregnancy. |
| doi_str_mv | 10.1053/plac.2001.0781 |
| format | Article |
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In addition to playing their traditional roles as modulators of immunological function, cytokines derived from the placenta and extraplacental membranes, together with other locally-derived growth factors, appear to be implicated in various aspects of implantation and placental development. Imbalances in the intrauterine cytokine milieu around the time of implantation and invasion may play a causative role in disorders associated with early pregnancy failure, and are also associated with the abnormal trophoblast development seen in gestational trophoblastic disease. Cytokines thus appear to be an important component of a paracrine/autocrine communication network operating within the feto-maternal interface to ensure the successful establishment of pregnancy.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1053/plac.2001.0781</identifier><identifier>PMID: 11969335</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Abortion, Habitual - immunology ; Biological and medical sciences ; Chemokines - physiology ; Cytokines - physiology ; Embryo Implantation - immunology ; Embryo Implantation - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Growth Substances - physiology ; Humans ; Interferons - physiology ; Maternal-Fetal Exchange - immunology ; Maternal-Fetal Exchange - physiology ; Mother. Fetoplacental unit. Mammary gland. Milk ; Placenta - immunology ; Placenta - physiology ; Placentation ; Pregnancy ; Pregnancy. Parturition. Lactation ; Transforming Growth Factor beta - physiology ; Trophoblastic Neoplasms - immunology ; Uterine Neoplasms - immunology ; Vertebrates: reproduction</subject><ispartof>Placenta (Eastbourne), 2002-04, Vol.23 (4), p.239-256</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Elsevier Science Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-87d8db045c1941a3fc685e05f7f5f7ca3cd7c3ab2e2c967bf57c0cd0a92771f3</citedby><cites>FETCH-LOGICAL-c436t-87d8db045c1941a3fc685e05f7f5f7ca3cd7c3ab2e2c967bf57c0cd0a92771f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143400401907817$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13647056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11969335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bowen, J.M.</creatorcontrib><creatorcontrib>Chamley, L.</creatorcontrib><creatorcontrib>Mitchell, M.D.</creatorcontrib><creatorcontrib>Keelan, J.A.</creatorcontrib><title>Cytokines of the Placenta and Extra-placental Membranes: Biosynthesis, Secretion and Roles in Establishment of Pregnancy in Women</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Virtually all known cytokines have been demonstrated to be expressed in the placenta and associated fetal and maternal membranes during normal gestation. In addition to playing their traditional roles as modulators of immunological function, cytokines derived from the placenta and extraplacental membranes, together with other locally-derived growth factors, appear to be implicated in various aspects of implantation and placental development. Imbalances in the intrauterine cytokine milieu around the time of implantation and invasion may play a causative role in disorders associated with early pregnancy failure, and are also associated with the abnormal trophoblast development seen in gestational trophoblastic disease. Cytokines thus appear to be an important component of a paracrine/autocrine communication network operating within the feto-maternal interface to ensure the successful establishment of pregnancy.</description><subject>Abortion, Habitual - immunology</subject><subject>Biological and medical sciences</subject><subject>Chemokines - physiology</subject><subject>Cytokines - physiology</subject><subject>Embryo Implantation - immunology</subject><subject>Embryo Implantation - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Substances - physiology</subject><subject>Humans</subject><subject>Interferons - physiology</subject><subject>Maternal-Fetal Exchange - immunology</subject><subject>Maternal-Fetal Exchange - physiology</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Placenta - immunology</subject><subject>Placenta - physiology</subject><subject>Placentation</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Transforming Growth Factor beta - physiology</subject><subject>Trophoblastic Neoplasms - immunology</subject><subject>Uterine Neoplasms - immunology</subject><subject>Vertebrates: reproduction</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFv1DAQRi0EotvClSPyBU7NMo6TOOEGq4UitaKCShwtZzKhhsTe2tmKPfLPcdhIPfVgWbLf99nzGHslYC2glO92g8F1DiDWoGrxhK1EKfNMCsifshWIQmYFQHHCTmP8BQBNIfLn7ESIpmqkLFfs7-Yw-d_WUeS-59Mt8evUSG4y3LiOb_9MwWS75WjgVzS2wST6Pf9ofTy4lIg2nvPvhIEm693_2Dc_pELr-DZOph1svB1Tfn7hOtBPZxwe5tsfPh2_YM96M0R6uexn7ObT9mZzkV1-_fxl8-Eyw0JWU1arru5aKEoUaQgje6zqkqDsVZ8WGomdQmnanHJsKtX2pULADkyTKyV6ecbeHmt3wd_tKU56tBFpGNI0fh-1ElUuRAUJXB9BDD7GQL3eBTuacNAC9Oxczzr07FzPzlPg9dK8b0fqHvBFcgLeLICJaIY-CUQbHzhZFQrKKnH1kaOk4d5S0BEtOaTOBsJJd94-9od_GkyfHA</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Bowen, J.M.</creator><creator>Chamley, L.</creator><creator>Mitchell, M.D.</creator><creator>Keelan, J.A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Cytokines of the Placenta and Extra-placental Membranes: Biosynthesis, Secretion and Roles in Establishment of Pregnancy in Women</title><author>Bowen, J.M. ; Chamley, L. ; Mitchell, M.D. ; Keelan, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-87d8db045c1941a3fc685e05f7f5f7ca3cd7c3ab2e2c967bf57c0cd0a92771f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Abortion, Habitual - immunology</topic><topic>Biological and medical sciences</topic><topic>Chemokines - physiology</topic><topic>Cytokines - physiology</topic><topic>Embryo Implantation - immunology</topic><topic>Embryo Implantation - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Substances - physiology</topic><topic>Humans</topic><topic>Interferons - physiology</topic><topic>Maternal-Fetal Exchange - immunology</topic><topic>Maternal-Fetal Exchange - physiology</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Placenta - immunology</topic><topic>Placenta - physiology</topic><topic>Placentation</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Transforming Growth Factor beta - physiology</topic><topic>Trophoblastic Neoplasms - immunology</topic><topic>Uterine Neoplasms - immunology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowen, J.M.</creatorcontrib><creatorcontrib>Chamley, L.</creatorcontrib><creatorcontrib>Mitchell, M.D.</creatorcontrib><creatorcontrib>Keelan, J.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowen, J.M.</au><au>Chamley, L.</au><au>Mitchell, M.D.</au><au>Keelan, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokines of the Placenta and Extra-placental Membranes: Biosynthesis, Secretion and Roles in Establishment of Pregnancy in Women</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>23</volume><issue>4</issue><spage>239</spage><epage>256</epage><pages>239-256</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><abstract>Virtually all known cytokines have been demonstrated to be expressed in the placenta and associated fetal and maternal membranes during normal gestation. In addition to playing their traditional roles as modulators of immunological function, cytokines derived from the placenta and extraplacental membranes, together with other locally-derived growth factors, appear to be implicated in various aspects of implantation and placental development. Imbalances in the intrauterine cytokine milieu around the time of implantation and invasion may play a causative role in disorders associated with early pregnancy failure, and are also associated with the abnormal trophoblast development seen in gestational trophoblastic disease. Cytokines thus appear to be an important component of a paracrine/autocrine communication network operating within the feto-maternal interface to ensure the successful establishment of pregnancy.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11969335</pmid><doi>10.1053/plac.2001.0781</doi><tpages>18</tpages></addata></record> |
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| subjects | Abortion, Habitual - immunology Biological and medical sciences Chemokines - physiology Cytokines - physiology Embryo Implantation - immunology Embryo Implantation - physiology Female Fundamental and applied biological sciences. Psychology Growth Substances - physiology Humans Interferons - physiology Maternal-Fetal Exchange - immunology Maternal-Fetal Exchange - physiology Mother. Fetoplacental unit. Mammary gland. Milk Placenta - immunology Placenta - physiology Placentation Pregnancy Pregnancy. Parturition. Lactation Transforming Growth Factor beta - physiology Trophoblastic Neoplasms - immunology Uterine Neoplasms - immunology Vertebrates: reproduction |
| title | Cytokines of the Placenta and Extra-placental Membranes: Biosynthesis, Secretion and Roles in Establishment of Pregnancy in Women |
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