Clearance of apoptotic beta-cells is reduced in neonatal autoimmune diabetes-prone rats

The kinetics of beta-cell death in neonatal diabetes-prone (BBdp) and diabetes-resistant (BBdr) BioBreeding rats was investigated using both direct (histochemical) and indirect (mathematical modelling) techniques. In both BBdp and BBdr rats, the incidence of TUNEL positive beta-cells increased until...

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Veröffentlicht in:	Cell death and differentiation 2002-04, Vol.9 (4), p.457-464
Hauptverfasser:	O'Brien, B A, Fieldus, W E, Field, C J, Finegood, D T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Female Insulin - analysis Islets of Langerhans - metabolism Islets of Langerhans - ultrastructure Macrophages - metabolism Male Phagocytosis Rats Thymus Gland - cytology Thymus Gland - metabolism
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Zusammenfassung:	The kinetics of beta-cell death in neonatal diabetes-prone (BBdp) and diabetes-resistant (BBdr) BioBreeding rats was investigated using both direct (histochemical) and indirect (mathematical modelling) techniques. In both BBdp and BBdr rats, the incidence of TUNEL positive beta-cells increased until 10 days of age before declining. The number of apoptotic beta-cells was significantly higher in BBdp as compared to BBdr neonates from birth until 20 days of age (P
ISSN:	1350-9047 1476-5403
DOI:	10.1038/sj.cdd.4400973