Comparison of the Dynamics of Substrate Access Channels in Three Cytochrome P450s Reveals Different Opening Mechanisms and a Novel Functional Role for a Buried Arginine

Understanding the mechanism and specificity of substrate binding in the cytochrome P450 (P450) superfamily is an important step toward explaining its key role in drug metabolism, toxicity, xenobiotic degradation, and several biosynthetic pathways. Here we investigate the ligand exit pathways and mec...

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