Apparent diffusion coefficient in pancreatic cancer: Characterization and histopathological correlations
Purpose To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue. Materials and Methods Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion‐weighted (DW) echo‐planar imaging (b value = 0, 500 s/mm2) was employed to c...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2008-06, Vol.27 (6), p.1302-1308 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Muraoka, Noriaki Uematsu, Hidemasa Kimura, Hirohiko Imamura, Yoshiaki Fujiwara, Yasuhiro Murakami, Makoto Yamaguchi, Akio Itoh, Harumi |
| description | Purpose
To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue.
Materials and Methods
Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion‐weighted (DW) echo‐planar imaging (b value = 0, 500 s/mm2) was employed to calculate the apparent diffusion coefficient (ADC). ADC values of cancer and noncancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results.
Results
The mean (±standard deviation) ADC value was significantly lower for tumor (1.27 ± 0.52 × 10−3 mm2/s) than for noncancerous tissue (1.90 ± 0.41 × 10−3 mm2/s, P < 0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis, and mucin in each case. Regarding the density of fibrosis in cancer, three cases were classified in the loose fibrosis group and the remaining seven cases were classified in the dense fibrosis group. The mean ADC value was significantly higher in the loose fibrosis group (1.88 ± 0.39 × 10−3 mm2/s) than in the dense fibrosis group (1.01 ± 0.29 × 10−3 mm2/s, P < 0.05). In quantitative analysis, ADC correlated well with the proportion of collagenous fibers (r = −0.87, P < 0.05).
Conclusion
Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer. J. Magn. Reson. Imaging 2008;27:1302–1308. © 2008 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.21340 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71620418</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71620418</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4550-f92b1cce3bafb68f9b9265be1437ef2108d1bc63912e14ab8aa381487aab7bd03</originalsourceid><addsrcrecordid>eNp9kEtP3DAUha2qqLy66Q9AWXVRKeBHnDjs0JSnpkVCIJbWtXPdMWSSYGfE49fjYaawY3Wvjr7zLQ4hPxjdZ5Tyg7t58PuciYJ-IVtMcp5zqcqv6adS5EzRapNsx3hHKa3rQn4jm0xJWlSSbpHZ0TBAwG7MGu_cIvq-y2yPznnrl6nvsgE6GxBGbzObXgyH2WQGAeyIwb-kPFWga7KZj2M_wDjr2_6ft9AmUQjYvhFxl2w4aCN-X98dcnNyfD05y6eXp-eTo2luCylp7mpumLUoDDhTKlebmpfSICtEhY4zqhpmbClqxlMGRgEIxQpVAZjKNFTskJ8r7xD6hwXGUc99tNi20GG_iLpiJacFUwn8tQJt6GMM6PQQ_BzCs2ZUL3fVy131264J3ltbF2aOzQe6HjIBbAU8-hafP1Hpiz9X5_-l-aqThsOn9w6Ee11WopL69u-p5lP-W53UQtfiFXaMlJ8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71620418</pqid></control><display><type>article</type><title>Apparent diffusion coefficient in pancreatic cancer: Characterization and histopathological correlations</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Muraoka, Noriaki ; Uematsu, Hidemasa ; Kimura, Hirohiko ; Imamura, Yoshiaki ; Fujiwara, Yasuhiro ; Murakami, Makoto ; Yamaguchi, Akio ; Itoh, Harumi</creator><creatorcontrib>Muraoka, Noriaki ; Uematsu, Hidemasa ; Kimura, Hirohiko ; Imamura, Yoshiaki ; Fujiwara, Yasuhiro ; Murakami, Makoto ; Yamaguchi, Akio ; Itoh, Harumi</creatorcontrib><description>Purpose
To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue.
Materials and Methods
Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion‐weighted (DW) echo‐planar imaging (b value = 0, 500 s/mm2) was employed to calculate the apparent diffusion coefficient (ADC). ADC values of cancer and noncancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results.
Results
The mean (±standard deviation) ADC value was significantly lower for tumor (1.27 ± 0.52 × 10−3 mm2/s) than for noncancerous tissue (1.90 ± 0.41 × 10−3 mm2/s, P < 0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis, and mucin in each case. Regarding the density of fibrosis in cancer, three cases were classified in the loose fibrosis group and the remaining seven cases were classified in the dense fibrosis group. The mean ADC value was significantly higher in the loose fibrosis group (1.88 ± 0.39 × 10−3 mm2/s) than in the dense fibrosis group (1.01 ± 0.29 × 10−3 mm2/s, P < 0.05). In quantitative analysis, ADC correlated well with the proportion of collagenous fibers (r = −0.87, P < 0.05).
Conclusion
Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer. J. Magn. Reson. Imaging 2008;27:1302–1308. © 2008 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.21340</identifier><identifier>PMID: 18504750</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; apparent diffusion coefficient ; Contrast Media - administration & dosage ; Diffusion Magnetic Resonance Imaging - methods ; diffusion-weighted imaging ; Echo-Planar Imaging - methods ; Female ; Fibrosis - pathology ; histopathological correlations ; Humans ; Image Enhancement - methods ; Image Processing, Computer-Assisted - methods ; Male ; Middle Aged ; Mucins ; Necrosis - pathology ; Observer Variation ; Pancreas - pathology ; Pancreas - ultrastructure ; pancreatic cancer ; Pancreatic Neoplasms - diagnosis ; Reproducibility of Results</subject><ispartof>Journal of magnetic resonance imaging, 2008-06, Vol.27 (6), p.1302-1308</ispartof><rights>Copyright © 2008 Wiley‐Liss, Inc.</rights><rights>2008 Wiley-Liss, Inc</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4550-f92b1cce3bafb68f9b9265be1437ef2108d1bc63912e14ab8aa381487aab7bd03</citedby><cites>FETCH-LOGICAL-c4550-f92b1cce3bafb68f9b9265be1437ef2108d1bc63912e14ab8aa381487aab7bd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.21340$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.21340$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18504750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muraoka, Noriaki</creatorcontrib><creatorcontrib>Uematsu, Hidemasa</creatorcontrib><creatorcontrib>Kimura, Hirohiko</creatorcontrib><creatorcontrib>Imamura, Yoshiaki</creatorcontrib><creatorcontrib>Fujiwara, Yasuhiro</creatorcontrib><creatorcontrib>Murakami, Makoto</creatorcontrib><creatorcontrib>Yamaguchi, Akio</creatorcontrib><creatorcontrib>Itoh, Harumi</creatorcontrib><title>Apparent diffusion coefficient in pancreatic cancer: Characterization and histopathological correlations</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue.
Materials and Methods
Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion‐weighted (DW) echo‐planar imaging (b value = 0, 500 s/mm2) was employed to calculate the apparent diffusion coefficient (ADC). ADC values of cancer and noncancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results.
Results
The mean (±standard deviation) ADC value was significantly lower for tumor (1.27 ± 0.52 × 10−3 mm2/s) than for noncancerous tissue (1.90 ± 0.41 × 10−3 mm2/s, P < 0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis, and mucin in each case. Regarding the density of fibrosis in cancer, three cases were classified in the loose fibrosis group and the remaining seven cases were classified in the dense fibrosis group. The mean ADC value was significantly higher in the loose fibrosis group (1.88 ± 0.39 × 10−3 mm2/s) than in the dense fibrosis group (1.01 ± 0.29 × 10−3 mm2/s, P < 0.05). In quantitative analysis, ADC correlated well with the proportion of collagenous fibers (r = −0.87, P < 0.05).
Conclusion
Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer. J. Magn. Reson. Imaging 2008;27:1302–1308. © 2008 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>apparent diffusion coefficient</subject><subject>Contrast Media - administration & dosage</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>diffusion-weighted imaging</subject><subject>Echo-Planar Imaging - methods</subject><subject>Female</subject><subject>Fibrosis - pathology</subject><subject>histopathological correlations</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucins</subject><subject>Necrosis - pathology</subject><subject>Observer Variation</subject><subject>Pancreas - pathology</subject><subject>Pancreas - ultrastructure</subject><subject>pancreatic cancer</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Reproducibility of Results</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP3DAUha2qqLy66Q9AWXVRKeBHnDjs0JSnpkVCIJbWtXPdMWSSYGfE49fjYaawY3Wvjr7zLQ4hPxjdZ5Tyg7t58PuciYJ-IVtMcp5zqcqv6adS5EzRapNsx3hHKa3rQn4jm0xJWlSSbpHZ0TBAwG7MGu_cIvq-y2yPznnrl6nvsgE6GxBGbzObXgyH2WQGAeyIwb-kPFWga7KZj2M_wDjr2_6ft9AmUQjYvhFxl2w4aCN-X98dcnNyfD05y6eXp-eTo2luCylp7mpumLUoDDhTKlebmpfSICtEhY4zqhpmbClqxlMGRgEIxQpVAZjKNFTskJ8r7xD6hwXGUc99tNi20GG_iLpiJacFUwn8tQJt6GMM6PQQ_BzCs2ZUL3fVy131264J3ltbF2aOzQe6HjIBbAU8-hafP1Hpiz9X5_-l-aqThsOn9w6Ee11WopL69u-p5lP-W53UQtfiFXaMlJ8</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Muraoka, Noriaki</creator><creator>Uematsu, Hidemasa</creator><creator>Kimura, Hirohiko</creator><creator>Imamura, Yoshiaki</creator><creator>Fujiwara, Yasuhiro</creator><creator>Murakami, Makoto</creator><creator>Yamaguchi, Akio</creator><creator>Itoh, Harumi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>Apparent diffusion coefficient in pancreatic cancer: Characterization and histopathological correlations</title><author>Muraoka, Noriaki ; Uematsu, Hidemasa ; Kimura, Hirohiko ; Imamura, Yoshiaki ; Fujiwara, Yasuhiro ; Murakami, Makoto ; Yamaguchi, Akio ; Itoh, Harumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4550-f92b1cce3bafb68f9b9265be1437ef2108d1bc63912e14ab8aa381487aab7bd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>apparent diffusion coefficient</topic><topic>Contrast Media - administration & dosage</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>diffusion-weighted imaging</topic><topic>Echo-Planar Imaging - methods</topic><topic>Female</topic><topic>Fibrosis - pathology</topic><topic>histopathological correlations</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucins</topic><topic>Necrosis - pathology</topic><topic>Observer Variation</topic><topic>Pancreas - pathology</topic><topic>Pancreas - ultrastructure</topic><topic>pancreatic cancer</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muraoka, Noriaki</creatorcontrib><creatorcontrib>Uematsu, Hidemasa</creatorcontrib><creatorcontrib>Kimura, Hirohiko</creatorcontrib><creatorcontrib>Imamura, Yoshiaki</creatorcontrib><creatorcontrib>Fujiwara, Yasuhiro</creatorcontrib><creatorcontrib>Murakami, Makoto</creatorcontrib><creatorcontrib>Yamaguchi, Akio</creatorcontrib><creatorcontrib>Itoh, Harumi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muraoka, Noriaki</au><au>Uematsu, Hidemasa</au><au>Kimura, Hirohiko</au><au>Imamura, Yoshiaki</au><au>Fujiwara, Yasuhiro</au><au>Murakami, Makoto</au><au>Yamaguchi, Akio</au><au>Itoh, Harumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apparent diffusion coefficient in pancreatic cancer: Characterization and histopathological correlations</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2008-06</date><risdate>2008</risdate><volume>27</volume><issue>6</issue><spage>1302</spage><epage>1308</epage><pages>1302-1308</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue.
Materials and Methods
Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion‐weighted (DW) echo‐planar imaging (b value = 0, 500 s/mm2) was employed to calculate the apparent diffusion coefficient (ADC). ADC values of cancer and noncancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results.
Results
The mean (±standard deviation) ADC value was significantly lower for tumor (1.27 ± 0.52 × 10−3 mm2/s) than for noncancerous tissue (1.90 ± 0.41 × 10−3 mm2/s, P < 0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis, and mucin in each case. Regarding the density of fibrosis in cancer, three cases were classified in the loose fibrosis group and the remaining seven cases were classified in the dense fibrosis group. The mean ADC value was significantly higher in the loose fibrosis group (1.88 ± 0.39 × 10−3 mm2/s) than in the dense fibrosis group (1.01 ± 0.29 × 10−3 mm2/s, P < 0.05). In quantitative analysis, ADC correlated well with the proportion of collagenous fibers (r = −0.87, P < 0.05).
Conclusion
Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer. J. Magn. Reson. Imaging 2008;27:1302–1308. © 2008 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18504750</pmid><doi>10.1002/jmri.21340</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over apparent diffusion coefficient Contrast Media - administration & dosage Diffusion Magnetic Resonance Imaging - methods diffusion-weighted imaging Echo-Planar Imaging - methods Female Fibrosis - pathology histopathological correlations Humans Image Enhancement - methods Image Processing, Computer-Assisted - methods Male Middle Aged Mucins Necrosis - pathology Observer Variation Pancreas - pathology Pancreas - ultrastructure pancreatic cancer Pancreatic Neoplasms - diagnosis Reproducibility of Results |
| title | Apparent diffusion coefficient in pancreatic cancer: Characterization and histopathological correlations |
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