The Absence of Acute Tolerance During Remifentanil Infusion in Volunteers

The development of acute opioid tolerance in humans remains controversial. We tested the hypothesis that continuous remifentanil infusion leads to rapid development of opioid tolerance. Twenty healthy male volunteers were enrolled onto a randomized, placebo-controlled, double-blinded, cross-over des...

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Veröffentlicht in:	Anesthesia and analgesia 2002-05, Vol.94 (5), p.1223-1228
Hauptverfasser:	Gustorff, Burkhard, Nahlik, Gabriele, Hoerauf, Klaus H., Kress, Hans G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics Analgesics, Opioid - pharmacology Biological and medical sciences Cross-Over Studies Double-Blind Method Drug Tolerance Humans Male Medical sciences Neuropharmacology Pain Threshold - drug effects Pharmacology. Drug treatments Piperidines - pharmacology Remifentanil
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