Tsg101: HIV-1's ticket to ride
Recent studies implicate the vacuolar protein-sorting pathway in the transport of the retroviral structural precursor (Gag) protein to its budding site on the plasma membrane of infected cells. This exploitation of the cellular endocytic trafficking machinery to release viral particles could lead to...
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| Veröffentlicht in: | Trends in microbiology (Regular ed.) 2002-05, Vol.10 (5), p.203-205 |
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| container_title | Trends in microbiology (Regular ed.) |
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| creator | Carter, Carol A |
| description | Recent studies implicate the vacuolar protein-sorting pathway in the transport of the retroviral structural precursor (Gag) protein to its budding site on the plasma membrane of infected cells. This exploitation of the cellular endocytic trafficking machinery to release viral particles could lead to the identification of virus-specific modulators and provide opportunities to design new targeted anti-viral agents.
A constituent of the cellular endocytic trafficking machinery, Tsg101, has been shown to bind the L domain of HIV-1 Gag, and this interaction could be essential for viral budding. |
| doi_str_mv | 10.1016/S0966-842X(02)02350-8 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0966-842X |
| ispartof | Trends in microbiology (Regular ed.), 2002-05, Vol.10 (5), p.203-205 |
| issn | 0966-842X 1878-4380 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine Triphosphatases DNA-Binding Proteins - metabolism endosomal pathway Endosomal Sorting Complexes Required for Transport Fungal Proteins - metabolism Gag Gene Products, gag - chemistry Gene Products, gag - metabolism HIV-1 HIV-1 - growth & development HIV-1 - metabolism Humans Protein Transport retroviruses Saccharomyces cerevisiae Proteins Transcription Factors - metabolism Tsg101/Vps23 ubiquiten Ubiquitin - metabolism vacular protein sorting pathway Vacuoles - metabolism virus asembly virus budding vps proteins |
| title | Tsg101: HIV-1's ticket to ride |
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