Expression of Nitrotyrosine and Oxidative Consequences in the Trabecular Meshwork of Patients with Primary Open-Angle Glaucoma

To evaluate the possible correlation between the visual field defects in patients with primary open-angle glaucoma (POAG) and the expression and enzymatic activity of nitric oxide synthase (NOS) isoenzymes and nitrotyrosine in trabecular meshwork (TM) samples. TM specimens were collected from 146 pa...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2008-06, Vol.49 (6), p.2506-2511
Hauptverfasser:	Fernandez-Durango, Raquel, Fernandez-Martinez, Amalia, Garcia-Feijoo, Julian, Castillo, Alfredo, de la Casa, Jose Martinez, Garcia-Bueno, Borja, Perez-Nievas, Beatriz G, Fernandez-Cruz, Arturo, Leza, Juan Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Calcium - pharmacology Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - physiology Glaucoma and intraocular pressure Glaucoma, Open-Angle - metabolism Humans Intraocular Pressure Lipid Peroxidation Malondialdehyde - metabolism Medical sciences Middle Aged Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type III - genetics Ophthalmology Oxidative Stress - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Trabecular Meshwork - metabolism Tyrosine - analogs & derivatives Tyrosine - metabolism Up-Regulation Vertebrates: nervous system and sense organs Vision Disorders - metabolism Visual Field Tests Visual Fields
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