Control of the Selectivity of the Aquaporin Water Channel Family by Global Orientational Tuning

Aquaporins are transmembrane channels found in cell membranes of all life forms. We examine their apparently paradoxical property, facilitation of efficient permeation of water while excluding protons, which is of critical importance to preserving the electrochemical potential across the cell membra...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-04, Vol.296 (5567), p.525-530
Hauptverfasser:	Tajkhorshid, Emad, Nollert, Peter, Jensen, Morten Ø., Larry J. W. Miercke, O'Connell, Joseph, Stroud, Robert M., Schulten, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Aquaporins - chemistry Aquaporins - genetics Aquaporins - metabolism Asparagine - chemistry Atoms Bacteria Biological and medical sciences Body water Cell membranes Cell physiology Cells Chemical Phenomena Chemistry, Physical Computer Simulation Crystallography, X-Ray Diffusion Electrochemistry Electron density Electrostatics Escherichia coli Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fundamental and applied biological sciences. Psychology Genetic aspects Glycerin Glycerol Glycerol - metabolism Hydrogen Hydrogen Bonding Hydrogen bonds Membrane and intracellular transports Membranes Models, Molecular Molecular and cellular biology Molecular dynamics Molecular orientation Molecules Mutation Oceans Paleoceanography Probability distributions Protein Conformation Protein Structure, Secondary Protons Static Electricity Surface water Water Water - chemistry Water - metabolism Water channels Water in the body
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