Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia
Candidate AIDS vaccines are based on the success of monkey studies, showing the ability of vaccine-induced cytotoxic T lymphocytes to control HIV-1 replication. We evaluated the ability to maintain suppression of virus replication in seroconverters with a naturally low level of plasma HIV-1 RNA. No...
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| Veröffentlicht in: | AIDS (London) 2002-03, Vol.16 (5), p.791-793 |
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| container_issue | 5 |
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| container_title | AIDS (London) |
| container_volume | 16 |
| creator | GOUDSMIT, Jaap BOGAARDS, Johannes A JURRIAANS, Suzanne SCHUITEMAKER, Hanneke LANGE, Joep M. A COUTINHO, Roel A WEVERLING, Gerrit Jan |
| description | Candidate AIDS vaccines are based on the success of monkey studies, showing the ability of vaccine-induced cytotoxic T lymphocytes to control HIV-1 replication. We evaluated the ability to maintain suppression of virus replication in seroconverters with a naturally low level of plasma HIV-1 RNA. No AIDS-defining events were observed at low plasma HIV-1-RNA levels, but a steady loss of CD4 T lymphocytes occurred, and long-term control of viraemia was extremely rare in the natural course of HIV-1 infection. |
| doi_str_mv | 10.1097/00002030-200203290-00016 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | AIDS (London), 2002-03, Vol.16 (5), p.791-793 |
| issn | 0269-9370 1473-5571 |
| language | eng |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; Journals@Ovid Complete |
| subjects | AIDS/HIV Biological and medical sciences CD4 antigen CD4 Lymphocyte Count Chemokine CXCL12 Chemokines, CXC - genetics Cohort Studies HIV Seropositivity - drug therapy HIV Seropositivity - immunology HIV Seropositivity - physiopathology HIV Seropositivity - virology HIV-1 - genetics HIV-1 - growth & development Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Prognosis Receptors, CCR5 - genetics RNA, Viral Time Factors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Viremia |
| title | Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia |
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