Somatic APC Inactivation Mechanisms in Sporadic Colorectal Cancer Cases in Hungary

The role of germline inactivation of the adenomatosis polyposis coli (APC) gene in hereditary colorectal cancer is well known, being the most important cause of familial adenomatosus polyposis (FAP) syndrome. Hereditary cases with germline mutations, however, account only for 5–10% of colorectal can...

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