Signaling Pathways Involved in IL-8-Dependent Activation of Adhesion Through Mac-1

In human neutrophils, IL-8 induces chemotaxis, the respiratory burst, and granule release, and enhances cellular adhesion, a beta(2) integrin-dependent event. IL-8 stimulates neutrophil adhesion to purified fibrinogen in a Mac-1-dependent manner. Mitogen-activated protein kinase (MAPK) activation wa...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-05, Vol.168 (9), p.4559-4566
Hauptverfasser:	Takami, Mimi, Terry, Valeri, Petruzzelli, Lilli
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion Cells, Cultured Enzyme Inhibitors - pharmacology ERK kinase Fibrinogen - metabolism Humans Interleukin-8 - pharmacology Kinetics Mac-1 antigen Macrophage-1 Antigen - physiology MAP Kinase Signaling System Mitogen-Activated Protein Kinases - antagonists & inhibitors Neutrophils - drug effects Neutrophils - immunology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - analysis Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Signal Transduction
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