6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with Antiviral Activity

6-Hydroxypyrimidines substituted at positions 2 and 4 by hydrogen, methyl, amino, cyclopropylamino, dimethylamino, methylsulfanyl, or hydroxyl group afford by the reaction with diisopropyl 2-(chloroethoxy)methylphosphonate in the presence of NaH, Cs2CO3, or DBU a mixture of N- and O6-[2-(diisopropyl...

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Veröffentlicht in:	Journal of medicinal chemistry 2002-04, Vol.45 (9), p.1918-1929
Hauptverfasser:	Holý, Antonín, Votruba, Ivan, Masojídková, Milena, Andrei, Graciela, Snoeck, Robert, Naesens, Lieve, De Clercq, Erik, Balzarini, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cell Division - drug effects Cell Line Humans Medical sciences Mice Organophosphonates - chemical synthesis Organophosphonates - chemistry Organophosphonates - pharmacology Pharmacology. Drug treatments Pyrimidine Nucleosides - chemical synthesis Pyrimidine Nucleosides - chemistry Pyrimidine Nucleosides - pharmacology Stereoisomerism Structure-Activity Relationship Tumor Cells, Cultured Virus Replication - drug effects
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