Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia

Chronic myeloid leukemia (CML) has been studied intensively for many years; yet its treatment remains problematic and its biology remains elusive. In chronic phase, the leukemic clone appears to be maintained by a small number of BCR-ABL-positive hematopoietic stem cells that differentiate normally...

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Veröffentlicht in:	Leukemia 2002-04, Vol.16 (4), p.549-558
Hauptverfasser:	HOLYOAKE, T. L, JIANG, X, DRUMMOND, M. W, EAVES, A. C, EAVES, C. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antigens, CD - metabolism Autocrine signalling BCR-ABL protein Biological and medical sciences Cell differentiation Cell Division Cell self-renewal Chromosome Aberrations Chromosomes Chronic myeloid leukemia Cloning Deregulation Development and progression Differentiation Fusion protein Fusion Proteins, bcr-abl - metabolism Genetic aspects Granulocyte colony-stimulating factor Granulocytes Hematologic and hematopoietic diseases Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Humans Interleukin 3 Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Mutation Myeloid leukemia Physiological aspects Progenitor cells Progeny Regulatory mechanisms (biology) Stem cells Telomere - physiology
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