Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition

Bloom's syndrome (BS) arises through mutations in both copies of the BLM gene that encodes a RecQ 3'-5' DNA helicase. BS patients are predisposed to developing all the cancers that affect the general population, and BS cells exhibit marked genetic instability. We showed recently that...

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Veröffentlicht in:	Oncogene 2002-03, Vol.21 (13), p.2079-2088
Hauptverfasser:	ABABOU, Mouna, DUMAIRE, Virginie, LEDUSE, Yann, AMOR-GUERET, Mounira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - deficiency Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins Biological and medical sciences Biotechnology BLM gene BLM protein Bloom Syndrome - genetics Bloom's syndrome Cancer Cell cycle Cell Cycle Proteins Cell Division - drug effects Cell Division - radiation effects Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosomes Complications and side effects Control Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism Deoxyribonucleic acid DNA DNA - biosynthesis DNA - drug effects DNA helicase DNA Helicases - deficiency DNA Helicases - genetics DNA Helicases - metabolism DNA Replication - drug effects DNA Replication - radiation effects DNA synthesis DNA-Binding Proteins Dosage and administration Flow Cytometry Fundamental and applied biological sciences. Psychology G2 Phase - drug effects G2 Phase - radiation effects Gene Expression Regulation - radiation effects Gene therapy Genetic aspects Genetic disorders Genomes Genomic instability Health aspects Health. Pharmaceutical industry Humans Hydroxyurea Hydroxyurea - pharmacology Industrial applications and implications. Economical aspects Ionizing radiation Kinases Mitosis - drug effects Mitosis - radiation effects Molecular and cellular biology Mutation p53 Protein Phosphorylation Phosphorylation - drug effects Protein-Serine-Threonine Kinases - metabolism Proteins Radiation RecQ Helicases RecQ protein Risk factors S phase S Phase - drug effects S Phase - radiation effects Time Factors Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins Ultraviolet radiation Ultraviolet Rays
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