Overexpression of B-type cyclins alters chromosomal segregation

To identify genes which overexpression results into chromosomal instability (CIN), we developed a biological approach based on a yeast indicator strain in which CIN can be detected by a sectoring phenotype. Screening in this strain of a yeast genomic library cloned into a high copy vector led us to...

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Veröffentlicht in:	Oncogene 2002-03, Vol.21 (13), p.2051-2057
Hauptverfasser:	SARAFAN-VASSEUR, Nasrin, LAMY, Aude, BOURGUIGNON, Jeannette, LE PESSOT, Florence, HIETER, Philip, SESBOÜE, Richard, BASTARD, Christian, FREBOURG, Thierry, FLAMAN, Jean-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Benomyl Benomyl - pharmacology Biological and medical sciences Cancer Cell cycle, cell proliferation Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular proteins Chromosome abnormalities Chromosome Segregation Chromosomes Chromosomes, Fungal - metabolism Cloning Colorectal cancer Complications and side effects Cyclin B - chemistry Cyclin B - genetics Cyclin B - metabolism Cyclin B1 Cyclin B2 Flow Cytometry Fundamental and applied biological sciences. Psychology Gene amplification Gene expression Gene Expression Regulation, Neoplastic Genes Genetic aspects Genomic instability Genotype & phenotype Humans Mitosis Molecular and cellular biology Molecular Sequence Data mRNA Mutation Neoplasms - genetics Neoplasms - metabolism Phenotypes Physiological aspects Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sectoring Sequence Homology, Amino Acid Spindle Apparatus - metabolism Tumors Yeast
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