Induced Formation of a DNA Bulge Structure by a Molecular Wedge Ligand−Postactivated Neocarzinostatin Chromophore

Our previous structure elucidation of the complexes of DNA and postactivated neocarzinostatin chromophore (NCS-chrom) compounds revealed two distinctly different binding modes of this antitumor molecule. A thorough understanding of these results will provide the molecular basis for the binding and D...

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Veröffentlicht in:	Biochemistry (Easton) 2002-04, Vol.41 (16), p.5131-5143
Hauptverfasser:	Gao, Xiaolian, Stassinopoulos, Adonis, Ji, Jie, Kwon, Youngjoo, Bare, Simona, Goldberg, Irving H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - metabolism Base Sequence Binding Sites Computer Simulation DNA, Single-Stranded - chemistry DNA, Single-Stranded - metabolism Enediynes Ligands Macromolecular Substances Models, Molecular Nuclear Magnetic Resonance, Biomolecular - methods Nucleic Acid Conformation - drug effects Sulfhydryl Reagents - chemistry Zinostatin - analogs & derivatives Zinostatin - chemistry Zinostatin - metabolism
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