New SRM Data Dependent Exclusion (MS)n Measurement for Structural Determination of Drug Metabolites Using LC/ESI/Ion Trap MS

New SRM (selected reaction monitoring) data dependent exclusion (MS)n measurement makes it possible to obtain MS3 fragmentation data for all MS2 fragments, useful for structural determination of drug metabolites using ESI ion trap. MS2 fragments are produced by cleavage of all protonated molecules a...

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Veröffentlicht in:	DRUG METABOLISM AND PHARMACOKINETICS 2003, Vol.18 (6), p.390-403
Hauptverfasser:	Tozuka, Zenzaburo, Kaneko, Hayato, Shiraga, Toshifumi, Beppu, Manabu, Niwa, Toshiro, Kawamura, Akio, Kagayama, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	(MS)n fragmentation data dependent measurement drug metabolism ESI MS protonated molecules structural determination
Online-Zugang:	Volltext
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