Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics
Background: Alcoholic patients show prominent disturbances of sleep electroencephalograms (EEGs) with a marked loss of slow wave sleep that is even more profound in African American alcoholics as compared to European Americans. Using partial sleep deprivation, this study examined the extent to which...
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Veröffentlicht in: | Biological psychiatry (1969) 2002-04, Vol.51 (8), p.632-641 |
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creator | Irwin, Michael Gillin, J.Christian Dang, Jeff Weissman, Jeffrey Phillips, Evie Ehlers, Cindy L |
description | Background: Alcoholic patients show prominent disturbances of sleep electroencephalograms (EEGs) with a marked loss of slow wave sleep that is even more profound in African American alcoholics as compared to European Americans. Using partial sleep deprivation, this study examined the extent to which abnormal sleep is reversible in alcoholic subjects.
Methods: In a sample stratified on ethnicity, polysomnographic and spectral sleep EEG measures were compared in male primary alcoholic in patients (
n=46) and age-matched comparison controls (
n=32) at baseline—and recovery sleep following a night of partial sleep deprivation.
Results: As compared to controls, alcoholic patients showed a loss of slow wave sleep and more spectral power in beta frequencies. Following sleep deprivation, slow wave sleep and delta power differentially changed between the groups. European American controls showed increases of slow wave sleep that were more robust than responses found in African American controls, whereas both alcoholic groups failed to show increases of slow wave sleep from baseline to recovery. Spectral EEG analyses revealed similar results; sleep deprivation induced significant increases of delta power during NREM-1 in the controls, but not in the alcoholics.
Conclusions: Alcohol dependence compromises the augmentation of slow wave sleep and delta power seen in healthy adults following sleep deprivation. The differential effect of alcoholism on sleep stage physiology suggests a defect in the regulation or plasticity of slow wave sleep with implications for theories linking sleep depth to morbidity and outcome in alcoholics. |
doi_str_mv | 10.1016/S0006-3223(01)01304-X |
format | Article |
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Methods: In a sample stratified on ethnicity, polysomnographic and spectral sleep EEG measures were compared in male primary alcoholic in patients (
n=46) and age-matched comparison controls (
n=32) at baseline—and recovery sleep following a night of partial sleep deprivation.
Results: As compared to controls, alcoholic patients showed a loss of slow wave sleep and more spectral power in beta frequencies. Following sleep deprivation, slow wave sleep and delta power differentially changed between the groups. European American controls showed increases of slow wave sleep that were more robust than responses found in African American controls, whereas both alcoholic groups failed to show increases of slow wave sleep from baseline to recovery. Spectral EEG analyses revealed similar results; sleep deprivation induced significant increases of delta power during NREM-1 in the controls, but not in the alcoholics.
Conclusions: Alcohol dependence compromises the augmentation of slow wave sleep and delta power seen in healthy adults following sleep deprivation. The differential effect of alcoholism on sleep stage physiology suggests a defect in the regulation or plasticity of slow wave sleep with implications for theories linking sleep depth to morbidity and outcome in alcoholics.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(01)01304-X</identifier><identifier>PMID: 11955463</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Addictive behaviors ; Adult ; Adult and adolescent clinical studies ; alcohol dependence ; Alcoholism ; Alcoholism - ethnology ; Alcoholism - physiopathology ; Analysis of Variance ; Biological and medical sciences ; Black or African American ; Black People ; Case-Control Studies ; Drug addictions ; Electroencephalography ; ethnicity ; Homeostasis ; Humans ; Male ; Medical sciences ; Middle Aged ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sleep ; sleep deprivation ; Sleep Deprivation - physiopathology ; Sleep Stages ; spectral analyses ; Toxicology ; White People</subject><ispartof>Biological psychiatry (1969), 2002-04, Vol.51 (8), p.632-641</ispartof><rights>2002 Society of Biological Psychiatry</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-98a5a2d64e4c54d681637d4518b1332c35c4f14596b3906ed85c5f98ca79aea33</citedby><cites>FETCH-LOGICAL-c391t-98a5a2d64e4c54d681637d4518b1332c35c4f14596b3906ed85c5f98ca79aea33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3223(01)01304-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13628665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11955463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irwin, Michael</creatorcontrib><creatorcontrib>Gillin, J.Christian</creatorcontrib><creatorcontrib>Dang, Jeff</creatorcontrib><creatorcontrib>Weissman, Jeffrey</creatorcontrib><creatorcontrib>Phillips, Evie</creatorcontrib><creatorcontrib>Ehlers, Cindy L</creatorcontrib><title>Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background: Alcoholic patients show prominent disturbances of sleep electroencephalograms (EEGs) with a marked loss of slow wave sleep that is even more profound in African American alcoholics as compared to European Americans. Using partial sleep deprivation, this study examined the extent to which abnormal sleep is reversible in alcoholic subjects.
Methods: In a sample stratified on ethnicity, polysomnographic and spectral sleep EEG measures were compared in male primary alcoholic in patients (
n=46) and age-matched comparison controls (
n=32) at baseline—and recovery sleep following a night of partial sleep deprivation.
Results: As compared to controls, alcoholic patients showed a loss of slow wave sleep and more spectral power in beta frequencies. Following sleep deprivation, slow wave sleep and delta power differentially changed between the groups. European American controls showed increases of slow wave sleep that were more robust than responses found in African American controls, whereas both alcoholic groups failed to show increases of slow wave sleep from baseline to recovery. Spectral EEG analyses revealed similar results; sleep deprivation induced significant increases of delta power during NREM-1 in the controls, but not in the alcoholics.
Conclusions: Alcohol dependence compromises the augmentation of slow wave sleep and delta power seen in healthy adults following sleep deprivation. The differential effect of alcoholism on sleep stage physiology suggests a defect in the regulation or plasticity of slow wave sleep with implications for theories linking sleep depth to morbidity and outcome in alcoholics.</description><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>alcohol dependence</subject><subject>Alcoholism</subject><subject>Alcoholism - ethnology</subject><subject>Alcoholism - physiopathology</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Case-Control Studies</subject><subject>Drug addictions</subject><subject>Electroencephalography</subject><subject>ethnicity</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Sleep</subject><subject>sleep deprivation</subject><subject>Sleep Deprivation - physiopathology</subject><subject>Sleep Stages</subject><subject>spectral analyses</subject><subject>Toxicology</subject><subject>White People</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtKxDAUBuAgio6XR1C6UXRRzcmt7UpEvMGA4AXchUx6qpFOMyadAd_ezEzRpatwyHeSn5-QQ6DnQEFdPFNKVc4Z46cUzihwKvK3DTKCsuA5E5RtktEv2SG7MX6msWAMtskOQCWlUHxEnp5bxFlW4yy4hemd7zITM5PNgp9g5pvsw0_Rxz5d2SyubMD3ebumrkvQTU34zkxr_YdvnY37ZKsxbcSD4dwjr7c3L9f3-fjx7uH6apxbXkGfV6WRhtVKoLBS1KoExYtaSCgnwDmzXFrRgJCVmvCKKqxLaWVTldYUlUHD-R45Wb-bsn7NMfZ66qLFtjUd-nnUBShaVLxMUK6hDT7GgI0eQmugelmmXpWpl01pCnpVpn5Le0fDB_PJFOu_raG9BI4HYKI1bRNMZ138c1yxUimZ3OXaYapj4TDoaB12FmsX0Pa69u6fKD9haJC4</recordid><startdate>20020415</startdate><enddate>20020415</enddate><creator>Irwin, Michael</creator><creator>Gillin, J.Christian</creator><creator>Dang, Jeff</creator><creator>Weissman, Jeffrey</creator><creator>Phillips, Evie</creator><creator>Ehlers, Cindy L</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020415</creationdate><title>Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics</title><author>Irwin, Michael ; Gillin, J.Christian ; Dang, Jeff ; Weissman, Jeffrey ; Phillips, Evie ; Ehlers, Cindy L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-98a5a2d64e4c54d681637d4518b1332c35c4f14596b3906ed85c5f98ca79aea33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Addictive behaviors</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>alcohol dependence</topic><topic>Alcoholism</topic><topic>Alcoholism - ethnology</topic><topic>Alcoholism - physiopathology</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Case-Control Studies</topic><topic>Drug addictions</topic><topic>Electroencephalography</topic><topic>ethnicity</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Sleep</topic><topic>sleep deprivation</topic><topic>Sleep Deprivation - physiopathology</topic><topic>Sleep Stages</topic><topic>spectral analyses</topic><topic>Toxicology</topic><topic>White People</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irwin, Michael</creatorcontrib><creatorcontrib>Gillin, J.Christian</creatorcontrib><creatorcontrib>Dang, Jeff</creatorcontrib><creatorcontrib>Weissman, Jeffrey</creatorcontrib><creatorcontrib>Phillips, Evie</creatorcontrib><creatorcontrib>Ehlers, Cindy L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irwin, Michael</au><au>Gillin, J.Christian</au><au>Dang, Jeff</au><au>Weissman, Jeffrey</au><au>Phillips, Evie</au><au>Ehlers, Cindy L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2002-04-15</date><risdate>2002</risdate><volume>51</volume><issue>8</issue><spage>632</spage><epage>641</epage><pages>632-641</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background: Alcoholic patients show prominent disturbances of sleep electroencephalograms (EEGs) with a marked loss of slow wave sleep that is even more profound in African American alcoholics as compared to European Americans. Using partial sleep deprivation, this study examined the extent to which abnormal sleep is reversible in alcoholic subjects.
Methods: In a sample stratified on ethnicity, polysomnographic and spectral sleep EEG measures were compared in male primary alcoholic in patients (
n=46) and age-matched comparison controls (
n=32) at baseline—and recovery sleep following a night of partial sleep deprivation.
Results: As compared to controls, alcoholic patients showed a loss of slow wave sleep and more spectral power in beta frequencies. Following sleep deprivation, slow wave sleep and delta power differentially changed between the groups. European American controls showed increases of slow wave sleep that were more robust than responses found in African American controls, whereas both alcoholic groups failed to show increases of slow wave sleep from baseline to recovery. Spectral EEG analyses revealed similar results; sleep deprivation induced significant increases of delta power during NREM-1 in the controls, but not in the alcoholics.
Conclusions: Alcohol dependence compromises the augmentation of slow wave sleep and delta power seen in healthy adults following sleep deprivation. The differential effect of alcoholism on sleep stage physiology suggests a defect in the regulation or plasticity of slow wave sleep with implications for theories linking sleep depth to morbidity and outcome in alcoholics.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11955463</pmid><doi>10.1016/S0006-3223(01)01304-X</doi><tpages>10</tpages></addata></record> |
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subjects | Addictive behaviors Adult Adult and adolescent clinical studies alcohol dependence Alcoholism Alcoholism - ethnology Alcoholism - physiopathology Analysis of Variance Biological and medical sciences Black or African American Black People Case-Control Studies Drug addictions Electroencephalography ethnicity Homeostasis Humans Male Medical sciences Middle Aged Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sleep sleep deprivation Sleep Deprivation - physiopathology Sleep Stages spectral analyses Toxicology White People |
title | Sleep deprivation as a probe of homeostatic sleep regulation in primary alcoholics |
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