Role of intracellular cationic liposome-DNA complex dissociation in transfection mediated by cationic lipids

The cationic lipid-mediated gene transfer process involves sequential steps: internalization of the cationic lipid-DNA complexes inside the cells via an endocytosis-like mechanism, escape from endosomes, dissociation of the complex, and finally entry of free DNA into the nucleus. However, cationic l...

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Veröffentlicht in:	DNA and cell biology 2002-02, Vol.21 (2), p.91-97
Hauptverfasser:	Cornelis, Sabine, Vandenbranden, Michel, Ruysschaert, Jean-Marie, Elouahabi, Abdelatif
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidines - administration & dosage Amidines - metabolism beta-Galactosidase - biosynthesis Biological Transport Cations - administration & dosage Cations - metabolism Cell Nucleus - metabolism Cytoplasm - metabolism DNA, Recombinant - administration & dosage DNA, Recombinant - metabolism Fluorescent Dyes - analysis Genes, Reporter HeLa Cells Humans Lac Operon Liposomes - administration & dosage Liposomes - metabolism Macromolecular Substances Microinjections Microscopy, Confocal Phosphatidylethanolamines - administration & dosage Phosphatidylethanolamines - metabolism Recombinant Fusion Proteins - biosynthesis Transfection - methods
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