Affinities of Packaging Domain Loops in HIV-1 RNA for the Nucleocapsid Protein

To design anti-nucleocapsid drugs, it is useful to know the affinities the protein has for its natural substrates under physiological conditions. Dissociation equilibrium constants are reported for seven RNA stem-loops bound to the mature HIV-1 nucleocapsid protein, NCp7. The loops include SL1, SL2,...

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Veröffentlicht in:	Biochemistry (Easton) 2002-04, Vol.41 (16), p.5276-5282
Hauptverfasser:	Shubsda, Michael F, Paoletti, Andrew C, Hudson, Bruce S, Borer, Philip N
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites Capsid - chemistry Capsid - metabolism Capsid Proteins gag Gene Products, Human Immunodeficiency Virus Gene Products, gag - chemistry Gene Products, gag - metabolism HIV-1 - physiology Kinetics Molecular Sequence Data Nucleic Acid Conformation Protein Structure, Tertiary RNA, Viral - chemistry RNA, Viral - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism Sodium Chloride - metabolism Spectrometry, Fluorescence Tryptophan - metabolism Viral Proteins Virus Assembly
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