Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke
To investigate the relation between plasma homocysteine (Hcy) and cerebral ischemic diseases and that between polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and cerebral ischemic diseases. The plasma homocysteine (Hcy) and genetic polymorphism of MTHFR among forty-nine cases with i...
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| Veröffentlicht in: | Zhong hua yi xue za zhi 2002-01, Vol.82 (2), p.119-122 |
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| creator | Huang, Yining Zhao Yl, Yu lan Li, Shunwei |
| description | To investigate the relation between plasma homocysteine (Hcy) and cerebral ischemic diseases and that between polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and cerebral ischemic diseases.
The plasma homocysteine (Hcy) and genetic polymorphism of MTHFR among forty-nine cases with ischemic cerebral diseases, including 25 with acute cerebral infarction (CI) and 25 with transient ischemic attacks (TIA), were investigated. Fifty-five age- and sex-matched healthy persons were used as controls. All the subjects underwent brain CT, carotid duplex, transcranial Doppler examination, plasma Vitamin B(12) and folic acid examination, besides examination of plasma Hcy and nucleotide 677 MTHFR genotypes. The effects of age, liver function, renal function, smoking, drinking, plasma vitamin B(12), and folic acid were analyzed.
The mean plasma Hcy was significantly higher in the CI group and TIA group (17.4 +/- 7.6 micromol/L and 16.6 +/- 5.2 micromol/L) compared with that in the control group (12.6 +/- 5.2 |
| format | Article |
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The plasma homocysteine (Hcy) and genetic polymorphism of MTHFR among forty-nine cases with ischemic cerebral diseases, including 25 with acute cerebral infarction (CI) and 25 with transient ischemic attacks (TIA), were investigated. Fifty-five age- and sex-matched healthy persons were used as controls. All the subjects underwent brain CT, carotid duplex, transcranial Doppler examination, plasma Vitamin B(12) and folic acid examination, besides examination of plasma Hcy and nucleotide 677 MTHFR genotypes. The effects of age, liver function, renal function, smoking, drinking, plasma vitamin B(12), and folic acid were analyzed.
The mean plasma Hcy was significantly higher in the CI group and TIA group (17.4 +/- 7.6 micromol/L and 16.6 +/- 5.2 micromol/L) compared with that in the control group (12.6 +/- 5.2</description><identifier>ISSN: 0376-2491</identifier><identifier>PMID: 11953142</identifier><language>chi</language><publisher>China</publisher><subject>Asian Continental Ancestry Group - genetics ; Brain Ischemia - blood ; Brain Ischemia - diagnosis ; Brain Ischemia - enzymology ; Brain Ischemia - genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Homocysteine - blood ; Humans ; Kidney Function Tests ; Male ; Methylenetetrahydrofolate Reductase (NADPH2) ; Middle Aged ; Mutation ; Oxidoreductases Acting on CH-NH Group Donors - genetics ; Prognosis ; Risk Factors ; Smoking - adverse effects ; Smoking - blood</subject><ispartof>Zhong hua yi xue za zhi, 2002-01, Vol.82 (2), p.119-122</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11953142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Yining</creatorcontrib><creatorcontrib>Zhao Yl, Yu lan</creatorcontrib><creatorcontrib>Li, Shunwei</creatorcontrib><title>Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke</title><title>Zhong hua yi xue za zhi</title><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><description>To investigate the relation between plasma homocysteine (Hcy) and cerebral ischemic diseases and that between polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and cerebral ischemic diseases.
The plasma homocysteine (Hcy) and genetic polymorphism of MTHFR among forty-nine cases with ischemic cerebral diseases, including 25 with acute cerebral infarction (CI) and 25 with transient ischemic attacks (TIA), were investigated. Fifty-five age- and sex-matched healthy persons were used as controls. All the subjects underwent brain CT, carotid duplex, transcranial Doppler examination, plasma Vitamin B(12) and folic acid examination, besides examination of plasma Hcy and nucleotide 677 MTHFR genotypes. The effects of age, liver function, renal function, smoking, drinking, plasma vitamin B(12), and folic acid were analyzed.
The mean plasma Hcy was significantly higher in the CI group and TIA group (17.4 +/- 7.6 micromol/L and 16.6 +/- 5.2 micromol/L) compared with that in the control group (12.6 +/- 5.2</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - enzymology</subject><subject>Brain Ischemia - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Kidney Function Tests</subject><subject>Male</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2)</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Oxidoreductases Acting on CH-NH Group Donors - genetics</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - blood</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10DFPwzAUBGAPIFpB_wLyxEQkP9u1mxFVQJEqscAcOfYzsZrEwXaG_HuKKNMtn06nuyJrJrSquKxhRTY5h5ZJLWrOONyQFUC9FSD5mvjDMmHq4hDtkguGER_pgKVbehyxYEmmW1yKPvamIE3oZltMRvqFv9KMjsbSYaIp5BP1xpaYMg0jDdl2OARLc0nxhHfk2ps-4-aSt-Tz5fljf6iO769v-6djNQHnpYKdtMK4FmpltQVptdgpy1vg3tYawTIlUCjmrJBGYWuc2TrY-VYCs-CduCUPf71Tit8z5tIM5yXY92bEOOdGg2Jiy_QZ3l_g3A7omimFwaSl-X9G_ACBoGJO</recordid><startdate>20020125</startdate><enddate>20020125</enddate><creator>Huang, Yining</creator><creator>Zhao Yl, Yu lan</creator><creator>Li, Shunwei</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020125</creationdate><title>Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke</title><author>Huang, Yining ; Zhao Yl, Yu lan ; Li, Shunwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-184c3adb196c7c14c7386c2b12fc97e1c063e360dc34a6ebada5d18fb410c1fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2002</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - diagnosis</topic><topic>Brain Ischemia - enzymology</topic><topic>Brain Ischemia - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Kidney Function Tests</topic><topic>Male</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2)</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Oxidoreductases Acting on CH-NH Group Donors - genetics</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - blood</topic><toplevel>online_resources</toplevel><creatorcontrib>Huang, Yining</creatorcontrib><creatorcontrib>Zhao Yl, Yu lan</creatorcontrib><creatorcontrib>Li, Shunwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Yining</au><au>Zhao Yl, Yu lan</au><au>Li, Shunwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2002-01-25</date><risdate>2002</risdate><volume>82</volume><issue>2</issue><spage>119</spage><epage>122</epage><pages>119-122</pages><issn>0376-2491</issn><abstract>To investigate the relation between plasma homocysteine (Hcy) and cerebral ischemic diseases and that between polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and cerebral ischemic diseases.
The plasma homocysteine (Hcy) and genetic polymorphism of MTHFR among forty-nine cases with ischemic cerebral diseases, including 25 with acute cerebral infarction (CI) and 25 with transient ischemic attacks (TIA), were investigated. Fifty-five age- and sex-matched healthy persons were used as controls. All the subjects underwent brain CT, carotid duplex, transcranial Doppler examination, plasma Vitamin B(12) and folic acid examination, besides examination of plasma Hcy and nucleotide 677 MTHFR genotypes. The effects of age, liver function, renal function, smoking, drinking, plasma vitamin B(12), and folic acid were analyzed.
The mean plasma Hcy was significantly higher in the CI group and TIA group (17.4 +/- 7.6 micromol/L and 16.6 +/- 5.2 micromol/L) compared with that in the control group (12.6 +/- 5.2</abstract><cop>China</cop><pmid>11953142</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Zhong hua yi xue za zhi, 2002-01, Vol.82 (2), p.119-122 |
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| language | chi |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Asian Continental Ancestry Group - genetics Brain Ischemia - blood Brain Ischemia - diagnosis Brain Ischemia - enzymology Brain Ischemia - genetics Female Gene Frequency Genetic Predisposition to Disease Homocysteine - blood Humans Kidney Function Tests Male Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Mutation Oxidoreductases Acting on CH-NH Group Donors - genetics Prognosis Risk Factors Smoking - adverse effects Smoking - blood |
| title | Hyperhomocysteine, methylenetetrahydrofolate reductase gene, and other risk factors in ischemic stroke |
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