Electrical communication between NAD-dependent enzyme and metal electrode using ferrocene-labeled NAD derivatives

Electrical communication between NAD-dependent enzyme and metal electrode using ferrocene-labeled NAD derivatives

The target N 6-ferrocene substituted NAD derivatives (ferrocene-labeled NAD, Fc-NAD) were synthesized as an electron-relay NAD cofactor. The synthesized NAD derivatives possessed some biological activites as substrates in the alcohol dehydrogenase systems. The oxidation current depended on both addi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of Bioscience and Bioengineering 2003, Vol.96 (6), p.585-587
Hauptverfasser: Kijima, Tatsuro, Suzuki, Tatsunori, Izumi, Taeko
Format: Artikel
Sprache:eng
Schlagworte:
alcohol dehydrogenase (ADH)
Biological and medical sciences
Biotechnology
cyclic voltammogram
ferrocene-labeled NAD (Fc-NAD)
Fundamental and applied biological sciences. Psychology
mediator
NAD-dependent enzyme
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The target N 6-ferrocene substituted NAD derivatives (ferrocene-labeled NAD, Fc-NAD) were synthesized as an electron-relay NAD cofactor. The synthesized NAD derivatives possessed some biological activites as substrates in the alcohol dehydrogenase systems. The oxidation current depended on both addition of ethanol and spacer length of Fc-NAD.
ISSN:1389-1723
1347-4421
DOI:10.1016/S1389-1723(04)70155-3