Antigenic variation of Anaplasma marginale msp2 occurs by combinatorial gene conversion

Summary The rickettsial pathogen Anaplasma marginale establishes lifelong persistent infection in the mammalian reservoir host, during which time immune escape variants continually arise in part because of variation in the expressed copy of the immunodominant outer membrane protein MSP2. A key quest...

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Veröffentlicht in:	Molecular microbiology 2002-03, Vol.43 (5), p.1151-1159
Hauptverfasser:	Brayton, Kelly A., Palmer, Guy H., Lundgren, Anna, Yi, Jooyoung, Barbet, Anthony F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anaplasma - genetics Anaplasma - immunology Antigenic Variation Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Base Sequence Gene Conversion Molecular Sequence Data Pseudogenes Recombination, Genetic Sequence Alignment
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