A randomized trial of choice of treatment in prostate cancer: the effect of intervention on the treatment chosen
OBJECTIVE To determine whether different approaches in the choice of treatment affect the treatment chosen by the patient for prostate cancer. PATIENTS AND METHODS We conducted a randomized trial with 210 men who had a histologically confirmed diagnosis of prostate cancer in 1993–94 at four major ho...
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| Veröffentlicht in: | BJU international 2004-01, Vol.93 (1), p.52-56 |
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| creator | Auvinen, A. Hakama, M. Ala‐Opas, M. Vornanen, T. Leppilahti, M. Salminen, P. Tammela, T.L.J. |
| description | OBJECTIVE
To determine whether different approaches in the choice of treatment affect the treatment chosen by the patient for prostate cancer.
PATIENTS AND METHODS
We conducted a randomized trial with 210 men who had a histologically confirmed diagnosis of prostate cancer in 1993–94 at four major hospitals in Finland. After obtaining informed consent the men were randomized either to an intervention arm, in which there was greater patient participation in the choice of treatment following a structured procedure, or a control arm in which the standard approach, i.e. a standardized treatment protocol, was used. The main outcome measure of the analysis was the primary treatment chosen for prostate cancer.
RESULTS
In the enhanced participation arm patients not eligible for radical prostatectomy chose orchidectomy less frequently and favoured nonsurgical endocrine treatment than in the treatment protocol arm. Radical prostatectomy was the most commonly chosen treatment option in both arms among men with operable cancer. The way treatment options were presented affected the treatment chosen for prostate cancer.
CONCLUSION
Patients with prostate cancer are willing and able to take an active role in making decisions. The preferences of patients with prostate cancer in the choice of treatment may differ from the priorities of the physicians. |
| doi_str_mv | 10.1111/j.1464-410X.2004.04554.x |
| format | Article |
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To determine whether different approaches in the choice of treatment affect the treatment chosen by the patient for prostate cancer.
PATIENTS AND METHODS
We conducted a randomized trial with 210 men who had a histologically confirmed diagnosis of prostate cancer in 1993–94 at four major hospitals in Finland. After obtaining informed consent the men were randomized either to an intervention arm, in which there was greater patient participation in the choice of treatment following a structured procedure, or a control arm in which the standard approach, i.e. a standardized treatment protocol, was used. The main outcome measure of the analysis was the primary treatment chosen for prostate cancer.
RESULTS
In the enhanced participation arm patients not eligible for radical prostatectomy chose orchidectomy less frequently and favoured nonsurgical endocrine treatment than in the treatment protocol arm. Radical prostatectomy was the most commonly chosen treatment option in both arms among men with operable cancer. The way treatment options were presented affected the treatment chosen for prostate cancer.
CONCLUSION
Patients with prostate cancer are willing and able to take an active role in making decisions. The preferences of patients with prostate cancer in the choice of treatment may differ from the priorities of the physicians.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2004.04554.x</identifier><identifier>PMID: 14678367</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Androgen Antagonists - therapeutic use ; Antineoplastic Agents, Hormonal - therapeutic use ; Biological and medical sciences ; Choice Behavior ; decision making ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Humans ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Orchiectomy - psychology ; Patient Participation ; prostate cancer ; Prostatectomy - psychology ; Prostatic Neoplasms - psychology ; Prostatic Neoplasms - therapy ; randomized controlled trial ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>BJU international, 2004-01, Vol.93 (1), p.52-56</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3954-6ca520fcd8b76950d9d962377a84e1a9d2a32c350e6d299f654a51c41050864f3</citedby><cites>FETCH-LOGICAL-c3954-6ca520fcd8b76950d9d962377a84e1a9d2a32c350e6d299f654a51c41050864f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2004.04554.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2004.04554.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,4022,27922,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15576635$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14678367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auvinen, A.</creatorcontrib><creatorcontrib>Hakama, M.</creatorcontrib><creatorcontrib>Ala‐Opas, M.</creatorcontrib><creatorcontrib>Vornanen, T.</creatorcontrib><creatorcontrib>Leppilahti, M.</creatorcontrib><creatorcontrib>Salminen, P.</creatorcontrib><creatorcontrib>Tammela, T.L.J.</creatorcontrib><title>A randomized trial of choice of treatment in prostate cancer: the effect of intervention on the treatment chosen</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>OBJECTIVE
To determine whether different approaches in the choice of treatment affect the treatment chosen by the patient for prostate cancer.
PATIENTS AND METHODS
We conducted a randomized trial with 210 men who had a histologically confirmed diagnosis of prostate cancer in 1993–94 at four major hospitals in Finland. After obtaining informed consent the men were randomized either to an intervention arm, in which there was greater patient participation in the choice of treatment following a structured procedure, or a control arm in which the standard approach, i.e. a standardized treatment protocol, was used. The main outcome measure of the analysis was the primary treatment chosen for prostate cancer.
RESULTS
In the enhanced participation arm patients not eligible for radical prostatectomy chose orchidectomy less frequently and favoured nonsurgical endocrine treatment than in the treatment protocol arm. Radical prostatectomy was the most commonly chosen treatment option in both arms among men with operable cancer. The way treatment options were presented affected the treatment chosen for prostate cancer.
CONCLUSION
Patients with prostate cancer are willing and able to take an active role in making decisions. The preferences of patients with prostate cancer in the choice of treatment may differ from the priorities of the physicians.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Androgen Antagonists - therapeutic use</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Choice Behavior</subject><subject>decision making</subject><subject>Gonadotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Orchiectomy - psychology</subject><subject>Patient Participation</subject><subject>prostate cancer</subject><subject>Prostatectomy - psychology</subject><subject>Prostatic Neoplasms - psychology</subject><subject>Prostatic Neoplasms - therapy</subject><subject>randomized controlled trial</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlKBDEQhoMo7q8gueht2nRn6Y7gQQdXBC8OeAuZdAUz9DImGbenN-2MztUQqCL1_ZWqHyGckyxP53SW5UywEcvJc1YQwjLCOGfZxwba_Sts_uZEih20F8KMkPQg-DbaSbGsqCh30fwCe93Vfeu-oMbRO93g3mLz0jsDQxY96NhCF7Hr8Nz3IeoI2OjOgD_D8QUwWAsmDqzrIvi3xLq-w-kO1bU-9QzQHaAtq5sAh6u4jybXV0_j29HD483d-OJhZKjkbCSM5gWxpq6mpZCc1LKWoqBlqSsGuZZ1oWlhKCcg6kJKKzjTPDdpcU4qwSzdRyfLvmnm1wWEqFoXDDSN7qBfBFXmXFaUFwmslqBJywUPVs29a7X_VDlRg9tqpgYj1WCqGtxWP26rjyQ9Wv2xmLZQr4UrexNwvAJ0MLqxyWrjwprjvBSC8sSdL7l318DnvwdQl_eTIaPfNK-bkA</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Auvinen, A.</creator><creator>Hakama, M.</creator><creator>Ala‐Opas, M.</creator><creator>Vornanen, T.</creator><creator>Leppilahti, M.</creator><creator>Salminen, P.</creator><creator>Tammela, T.L.J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>A randomized trial of choice of treatment in prostate cancer: the effect of intervention on the treatment chosen</title><author>Auvinen, A. ; Hakama, M. ; Ala‐Opas, M. ; Vornanen, T. ; Leppilahti, M. ; Salminen, P. ; Tammela, T.L.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3954-6ca520fcd8b76950d9d962377a84e1a9d2a32c350e6d299f654a51c41050864f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Androgen Antagonists - therapeutic use</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Choice Behavior</topic><topic>decision making</topic><topic>Gonadotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Orchiectomy - psychology</topic><topic>Patient Participation</topic><topic>prostate cancer</topic><topic>Prostatectomy - psychology</topic><topic>Prostatic Neoplasms - psychology</topic><topic>Prostatic Neoplasms - therapy</topic><topic>randomized controlled trial</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auvinen, A.</creatorcontrib><creatorcontrib>Hakama, M.</creatorcontrib><creatorcontrib>Ala‐Opas, M.</creatorcontrib><creatorcontrib>Vornanen, T.</creatorcontrib><creatorcontrib>Leppilahti, M.</creatorcontrib><creatorcontrib>Salminen, P.</creatorcontrib><creatorcontrib>Tammela, T.L.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auvinen, A.</au><au>Hakama, M.</au><au>Ala‐Opas, M.</au><au>Vornanen, T.</au><au>Leppilahti, M.</au><au>Salminen, P.</au><au>Tammela, T.L.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomized trial of choice of treatment in prostate cancer: the effect of intervention on the treatment chosen</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2004-01</date><risdate>2004</risdate><volume>93</volume><issue>1</issue><spage>52</spage><epage>56</epage><pages>52-56</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><abstract>OBJECTIVE
To determine whether different approaches in the choice of treatment affect the treatment chosen by the patient for prostate cancer.
PATIENTS AND METHODS
We conducted a randomized trial with 210 men who had a histologically confirmed diagnosis of prostate cancer in 1993–94 at four major hospitals in Finland. After obtaining informed consent the men were randomized either to an intervention arm, in which there was greater patient participation in the choice of treatment following a structured procedure, or a control arm in which the standard approach, i.e. a standardized treatment protocol, was used. The main outcome measure of the analysis was the primary treatment chosen for prostate cancer.
RESULTS
In the enhanced participation arm patients not eligible for radical prostatectomy chose orchidectomy less frequently and favoured nonsurgical endocrine treatment than in the treatment protocol arm. Radical prostatectomy was the most commonly chosen treatment option in both arms among men with operable cancer. The way treatment options were presented affected the treatment chosen for prostate cancer.
CONCLUSION
Patients with prostate cancer are willing and able to take an active role in making decisions. The preferences of patients with prostate cancer in the choice of treatment may differ from the priorities of the physicians.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14678367</pmid><doi>10.1111/j.1464-410X.2004.04554.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Androgen Antagonists - therapeutic use Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Choice Behavior decision making Gonadotropin-Releasing Hormone - antagonists & inhibitors Humans Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Orchiectomy - psychology Patient Participation prostate cancer Prostatectomy - psychology Prostatic Neoplasms - psychology Prostatic Neoplasms - therapy randomized controlled trial Tumors of the urinary system Urinary tract. Prostate gland |
| title | A randomized trial of choice of treatment in prostate cancer: the effect of intervention on the treatment chosen |
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