Equilibrium modeling of extractive enzymatic hydrolysis of penicillin G with concomitant 6-aminopenicillanic acid crystallization

In the present downstream processing of penicillin G, penicillin G is extracted from the fermentation broth with an organic solvent and purified as a potassium salt via a number of back‐extraction and crystallization steps. After purification, penicillin G is hydrolyzed to 6‐aminopenicillanic acid,...

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Veröffentlicht in:	Biotechnology and bioengineering 2002-05, Vol.78 (4), p.395-402
Hauptverfasser:	Diender, M. B., Straathof, A. J. J., van der Does, T., Ras, C., Heijnen, J. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - metabolism Antibiotics Biological and medical sciences Biotechnology Catalysis Chromatography, High Pressure Liquid - methods Computer Simulation Crystallization equilibrium prediction Escherichia coli - enzymology Fermentation Fundamental and applied biological sciences. Psychology Glycine - analogs & derivatives Glycine - chemistry Health. Pharmaceutical industry Hydrogen-Ion Concentration Hydrolysis Industrial applications and implications. Economical aspects Models, Chemical multiphase systems partitioning Penicillanic Acid - analogs & derivatives Penicillanic Acid - chemistry Penicillanic Acid - isolation & purification Penicillanic Acid - metabolism Penicillin Amidase - metabolism penicillin G Penicillin G - isolation & purification Penicillin G - metabolism Potassium - chemistry Production of active biomolecules Reproducibility of Results Sensitivity and Specificity Water - chemistry
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