The Genetic Epidemiology of Spontaneous Endometriosis in the Rhesus Monkey
: The etiology of endometriosis is uncertain, but there is increasing evidence that it is inherited as a complex genetic trait like diabetes or asthma. In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phen...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2002-03, Vol.955 (1), p.233-238 |
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| creator | ZONDERVAN, KRINA CARDON, LON DESROSIERS, RONALD HYDE, DALLAS KEMNITZ, JOSEPH MANSFIELD, KEITH ROBERTS, JEFF SCHEFFLER, JOAN WEEKS, DANIEL E. KENNEDY, STEPHEN |
| description | : The etiology of endometriosis is uncertain, but there is increasing evidence that it is inherited as a complex genetic trait like diabetes or asthma. In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phenotype. The study of such interactions in humans can be problematic. Thus, the availability of an animal model, which shares many aspects of anatomy and physiology with humans, is potentially a valuable tool for investigating the genetic epidemiology of the disease. Since endometriosis develops spontaneously in the rhesus monkey (Macaca mulatta) and the tissue is morphologically identical to its human counterpart, this population provides a unique opportunity to conduct such studies in this condition. |
| doi_str_mv | 10.1111/j.1749-6632.2002.tb02784.x |
| format | Article |
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In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phenotype. The study of such interactions in humans can be problematic. Thus, the availability of an animal model, which shares many aspects of anatomy and physiology with humans, is potentially a valuable tool for investigating the genetic epidemiology of the disease. 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In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phenotype. The study of such interactions in humans can be problematic. Thus, the availability of an animal model, which shares many aspects of anatomy and physiology with humans, is potentially a valuable tool for investigating the genetic epidemiology of the disease. Since endometriosis develops spontaneously in the rhesus monkey (Macaca mulatta) and the tissue is morphologically identical to its human counterpart, this population provides a unique opportunity to conduct such studies in this condition.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>endometriosis</subject><subject>Endometriosis - etiology</subject><subject>Endometriosis - genetics</subject><subject>epidemiology</subject><subject>Female</subject><subject>genetics</subject><subject>Macaca mulatta</subject><subject>Molecular Epidemiology</subject><subject>rhesus monkey</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE9P20AQxVdVUQmhX6GyeujNZv9vtpcKoTSAIJXqSNDTytkdlw22N3gdNfn22HJEz8xlDvPem5kfQl8JzkhfF5uMKK5TKRnNKMY069aYqhnP9h_Q5G30EU0wViqdacpO0VmMG4wJnXH1CZ0SornWgkzQ7eoJkgU00HmbzLfeQe1DFf4eklAm-TY0XdFA2MVk3rhQQ9f6EH1MfJN0vfH3E8R-dh-aZzico5OyqCJ8PvYpWv2cr66u07tfi5ury7vUcqxZKsFizhi1uFQCi1KTAqQF5wpHOFBmFVVYr7UlrlROWyn7j5SgnAnlqGRT9G2M3bbhZQexM7WPFqpqPNQoIrQUgvXC76PQtiHGFkqzbX1dtAdDsBlAmo0ZaJmBlhlAmiNIs-_NX45bdusa3H_rkVwv-DEK_vkKDu-INss_lzllw33pmOBjB_u3hKJ9NlIxJczDcmEeJc5zvsAmZ6_z3ZJV</recordid><startdate>200203</startdate><enddate>200203</enddate><creator>ZONDERVAN, KRINA</creator><creator>CARDON, LON</creator><creator>DESROSIERS, RONALD</creator><creator>HYDE, DALLAS</creator><creator>KEMNITZ, JOSEPH</creator><creator>MANSFIELD, KEITH</creator><creator>ROBERTS, JEFF</creator><creator>SCHEFFLER, JOAN</creator><creator>WEEKS, DANIEL E.</creator><creator>KENNEDY, STEPHEN</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200203</creationdate><title>The Genetic Epidemiology of Spontaneous Endometriosis in the Rhesus Monkey</title><author>ZONDERVAN, KRINA ; CARDON, LON ; DESROSIERS, RONALD ; HYDE, DALLAS ; KEMNITZ, JOSEPH ; MANSFIELD, KEITH ; ROBERTS, JEFF ; SCHEFFLER, JOAN ; WEEKS, DANIEL E. ; KENNEDY, STEPHEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4093-6ec04332c0f7505f91ae6ceddad14e23c72709b9c1df7d9c667497524357d263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>endometriosis</topic><topic>Endometriosis - etiology</topic><topic>Endometriosis - genetics</topic><topic>epidemiology</topic><topic>Female</topic><topic>genetics</topic><topic>Macaca mulatta</topic><topic>Molecular Epidemiology</topic><topic>rhesus monkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZONDERVAN, KRINA</creatorcontrib><creatorcontrib>CARDON, LON</creatorcontrib><creatorcontrib>DESROSIERS, RONALD</creatorcontrib><creatorcontrib>HYDE, DALLAS</creatorcontrib><creatorcontrib>KEMNITZ, JOSEPH</creatorcontrib><creatorcontrib>MANSFIELD, KEITH</creatorcontrib><creatorcontrib>ROBERTS, JEFF</creatorcontrib><creatorcontrib>SCHEFFLER, JOAN</creatorcontrib><creatorcontrib>WEEKS, DANIEL E.</creatorcontrib><creatorcontrib>KENNEDY, STEPHEN</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZONDERVAN, KRINA</au><au>CARDON, LON</au><au>DESROSIERS, RONALD</au><au>HYDE, DALLAS</au><au>KEMNITZ, JOSEPH</au><au>MANSFIELD, KEITH</au><au>ROBERTS, JEFF</au><au>SCHEFFLER, JOAN</au><au>WEEKS, DANIEL E.</au><au>KENNEDY, STEPHEN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Genetic Epidemiology of Spontaneous Endometriosis in the Rhesus Monkey</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2002-03</date><risdate>2002</risdate><volume>955</volume><issue>1</issue><spage>233</spage><epage>238</epage><pages>233-238</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: The etiology of endometriosis is uncertain, but there is increasing evidence that it is inherited as a complex genetic trait like diabetes or asthma. 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| subjects | Animals Disease Models, Animal endometriosis Endometriosis - etiology Endometriosis - genetics epidemiology Female genetics Macaca mulatta Molecular Epidemiology rhesus monkey |
| title | The Genetic Epidemiology of Spontaneous Endometriosis in the Rhesus Monkey |
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