Ankyrin G and voltage gated sodium channels colocalize in human neuroma – key proteins of membrane remodeling after axonal injury

We tested if ankyrin G could be detected in human neuroma, if it colocalized with site-specific peripheral nerve sodium channels that accumulate at axon tips of injured nerve, and if there are differences in the distribution of these proteins in non-painful neuroma and painful neuroma tissue vs. nor...

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Veröffentlicht in:	Neuroscience letters 2002-04, Vol.323 (2), p.151-155
Hauptverfasser:	Kretschmer, Thomas, England, John D., Happel, Leo T., Liu, Z.P., Thouron, Carol L., Nguyen, Doan H., Beuerman, Roger W., Kline, David G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ankyrin G Ankyrins - analysis Ankyrins - metabolism Axolemmal plasticity Axons - chemistry Axons - metabolism Axons - pathology Biological and medical sciences Cell Membrane - chemistry Cell Membrane - metabolism Cell Membrane - pathology Human neuroma Humans Immunocytochemistry Ion Channel Gating - physiology Medical sciences Membrane remodeling NAV1.8 Voltage-Gated Sodium Channel Nerve trauma Neurology Neuroma - chemistry Neuroma - metabolism Neuroma - pathology Neuropeptides - analysis Neuropeptides - metabolism Pain Patch-Clamp Techniques Sodium channels Sodium Channels - analysis Sodium Channels - metabolism Tumors of the nervous system. Phacomatoses
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