Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese
We sequenced all exons and exon-intron junctions of the flavin-containing monooxygenase 3 (FMO3) gene from 27 Japanese individuals who are trimethylaminuria volunteers judged by self-reported analysis. We found two novel single nucleotide polymorphisms (SNPs) (21246T>Aand 21265C>T) causing ami...
Gespeichert in:
| Veröffentlicht in: | DRUG METABOLISM AND PHARMACOKINETICS 2003, Vol.18 (5), p.333-335 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 335 |
|---|---|
| container_issue | 5 |
| container_start_page | 333 |
| container_title | DRUG METABOLISM AND PHARMACOKINETICS |
| container_volume | 18 |
| creator | Fujieda, Masaki Yamazaki, Hiroshi Togashi, Masahiro Saito, Tetsuya Kamataki, Tetsuya |
| description | We sequenced all exons and exon-intron junctions of the flavin-containing monooxygenase 3 (FMO3) gene from 27 Japanese individuals who are trimethylaminuria volunteers judged by self-reported analysis. We found two novel single nucleotide polymorphisms (SNPs) (21246T>Aand 21265C>T) causing amino acid substitutions (Asp198Glu and Arg205Cys in exon 5), respectively. The Asp198Glu allele also presented together with known SNPs (20852 C>T in exon4, 20960_20962 CTT deletion, 21115G>Ain intron 4, and 21243_21244 TG deletion in exon 5) in the same allele of the FMO3 gene to form a novel haplotype.
These sequences are as follows:1)SNP, 030609Fujieda019; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5′-TTCGGGCTG(TG/-)AT/AATTGCCACAGAA-3′.2)SNP, 030609Fujieda020; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5′-ACAGAACTCAGCC/TGCACAGCAGAAC-3′. |
| doi_str_mv | 10.2133/dmpk.18.333 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71594189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1347436715309010</els_id><sourcerecordid>71594189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4323-a167a031b1fcb9be882b8e1b3628673520838a07ec264c4a2b9f4ccbbefa65f3</originalsourceid><addsrcrecordid>eNptkM9rFDEUgAdR7A89eZecRJFZk7xJJnOU4lal3Ra695Bk39jUzGRMZir975tlF7x4yQvk4-Plq6p3jK44A_iyG6bfK6ZWAPCiOmVK0Zp2nL4sd2jaugHZnlRnOT9QCiAa_ro6YUIy1Qo4ra63fyPZxEcM5M6PvwKSzeICxtnvkNzG8DTENN37PGTy8W5zmz-R2JP5Hsn6-gbIJY5I_Eh-msmMmPFN9ao3IePb4zyvtutv24vv9dXN5Y-Lr1e1a4BDbZhsDQVmWe9sZ1EpbhUyC5Ir2YLgVIEytEXHZeMaw23XN85Zi72Roofz6sNBO6X4Z8E868FnhyGUJeKSdctE1zDVFfDzAXQp5pyw11Pyg0lPmlG9j6f38TRTusQr9PujdrED7v6xx1oFWB-A8uqdCXEMfkT9EJc0lu9qF9mAs7Gal9SaUqaoKEPpEh72h2iVhE4WkTiIsER69Jh0dh5HV7QJ3ax30f93w2eviJGe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71594189</pqid></control><display><type>article</type><title>Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese</title><source>J-STAGE Free</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Fujieda, Masaki ; Yamazaki, Hiroshi ; Togashi, Masahiro ; Saito, Tetsuya ; Kamataki, Tetsuya</creator><creatorcontrib>Fujieda, Masaki ; Yamazaki, Hiroshi ; Togashi, Masahiro ; Saito, Tetsuya ; Kamataki, Tetsuya ; Laboratory of Drug Metabolism ; Graduate School of Pharmaceutical Sciences ; Hokkaido University</creatorcontrib><description>We sequenced all exons and exon-intron junctions of the flavin-containing monooxygenase 3 (FMO3) gene from 27 Japanese individuals who are trimethylaminuria volunteers judged by self-reported analysis. We found two novel single nucleotide polymorphisms (SNPs) (21246T>Aand 21265C>T) causing amino acid substitutions (Asp198Glu and Arg205Cys in exon 5), respectively. The Asp198Glu allele also presented together with known SNPs (20852 C>T in exon4, 20960_20962 CTT deletion, 21115G>Ain intron 4, and 21243_21244 TG deletion in exon 5) in the same allele of the FMO3 gene to form a novel haplotype.
These sequences are as follows:1)SNP, 030609Fujieda019; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5′-TTCGGGCTG(TG/-)AT/AATTGCCACAGAA-3′.2)SNP, 030609Fujieda020; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5′-ACAGAACTCAGCC/TGCACAGCAGAAC-3′.</description><identifier>ISSN: 1347-4367</identifier><identifier>EISSN: 1880-0920</identifier><identifier>DOI: 10.2133/dmpk.18.333</identifier><identifier>PMID: 15618753</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>fish-odor syndrome ; Flavin-containing monooxygenase ; genetic polymorphism ; Japanese ; trimethylaminuria</subject><ispartof>DRUG METABOLISM AND PHARMACOKINETICS, 2003, Vol.18 (5), p.333-335</ispartof><rights>2003 The Japanese Society for the Study of Xenobiotics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4323-a167a031b1fcb9be882b8e1b3628673520838a07ec264c4a2b9f4ccbbefa65f3</citedby><cites>FETCH-LOGICAL-c4323-a167a031b1fcb9be882b8e1b3628673520838a07ec264c4a2b9f4ccbbefa65f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15618753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujieda, Masaki</creatorcontrib><creatorcontrib>Yamazaki, Hiroshi</creatorcontrib><creatorcontrib>Togashi, Masahiro</creatorcontrib><creatorcontrib>Saito, Tetsuya</creatorcontrib><creatorcontrib>Kamataki, Tetsuya</creatorcontrib><creatorcontrib>Laboratory of Drug Metabolism</creatorcontrib><creatorcontrib>Graduate School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Hokkaido University</creatorcontrib><title>Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese</title><title>DRUG METABOLISM AND PHARMACOKINETICS</title><addtitle>Drug Metab Pharmacokinet</addtitle><description>We sequenced all exons and exon-intron junctions of the flavin-containing monooxygenase 3 (FMO3) gene from 27 Japanese individuals who are trimethylaminuria volunteers judged by self-reported analysis. We found two novel single nucleotide polymorphisms (SNPs) (21246T>Aand 21265C>T) causing amino acid substitutions (Asp198Glu and Arg205Cys in exon 5), respectively. The Asp198Glu allele also presented together with known SNPs (20852 C>T in exon4, 20960_20962 CTT deletion, 21115G>Ain intron 4, and 21243_21244 TG deletion in exon 5) in the same allele of the FMO3 gene to form a novel haplotype.
These sequences are as follows:1)SNP, 030609Fujieda019; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5′-TTCGGGCTG(TG/-)AT/AATTGCCACAGAA-3′.2)SNP, 030609Fujieda020; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5′-ACAGAACTCAGCC/TGCACAGCAGAAC-3′.</description><subject>fish-odor syndrome</subject><subject>Flavin-containing monooxygenase</subject><subject>genetic polymorphism</subject><subject>Japanese</subject><subject>trimethylaminuria</subject><issn>1347-4367</issn><issn>1880-0920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNptkM9rFDEUgAdR7A89eZecRJFZk7xJJnOU4lal3Ra695Bk39jUzGRMZir975tlF7x4yQvk4-Plq6p3jK44A_iyG6bfK6ZWAPCiOmVK0Zp2nL4sd2jaugHZnlRnOT9QCiAa_ro6YUIy1Qo4ra63fyPZxEcM5M6PvwKSzeICxtnvkNzG8DTENN37PGTy8W5zmz-R2JP5Hsn6-gbIJY5I_Eh-msmMmPFN9ao3IePb4zyvtutv24vv9dXN5Y-Lr1e1a4BDbZhsDQVmWe9sZ1EpbhUyC5Ir2YLgVIEytEXHZeMaw23XN85Zi72Roofz6sNBO6X4Z8E868FnhyGUJeKSdctE1zDVFfDzAXQp5pyw11Pyg0lPmlG9j6f38TRTusQr9PujdrED7v6xx1oFWB-A8uqdCXEMfkT9EJc0lu9qF9mAs7Gal9SaUqaoKEPpEh72h2iVhE4WkTiIsER69Jh0dh5HV7QJ3ax30f93w2eviJGe</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Fujieda, Masaki</creator><creator>Yamazaki, Hiroshi</creator><creator>Togashi, Masahiro</creator><creator>Saito, Tetsuya</creator><creator>Kamataki, Tetsuya</creator><general>Elsevier Ltd</general><general>Japanese Society for the Study of Xenobiotics</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese</title><author>Fujieda, Masaki ; Yamazaki, Hiroshi ; Togashi, Masahiro ; Saito, Tetsuya ; Kamataki, Tetsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4323-a167a031b1fcb9be882b8e1b3628673520838a07ec264c4a2b9f4ccbbefa65f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>fish-odor syndrome</topic><topic>Flavin-containing monooxygenase</topic><topic>genetic polymorphism</topic><topic>Japanese</topic><topic>trimethylaminuria</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujieda, Masaki</creatorcontrib><creatorcontrib>Yamazaki, Hiroshi</creatorcontrib><creatorcontrib>Togashi, Masahiro</creatorcontrib><creatorcontrib>Saito, Tetsuya</creatorcontrib><creatorcontrib>Kamataki, Tetsuya</creatorcontrib><creatorcontrib>Laboratory of Drug Metabolism</creatorcontrib><creatorcontrib>Graduate School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Hokkaido University</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>DRUG METABOLISM AND PHARMACOKINETICS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujieda, Masaki</au><au>Yamazaki, Hiroshi</au><au>Togashi, Masahiro</au><au>Saito, Tetsuya</au><au>Kamataki, Tetsuya</au><aucorp>Laboratory of Drug Metabolism</aucorp><aucorp>Graduate School of Pharmaceutical Sciences</aucorp><aucorp>Hokkaido University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese</atitle><jtitle>DRUG METABOLISM AND PHARMACOKINETICS</jtitle><addtitle>Drug Metab Pharmacokinet</addtitle><date>2003</date><risdate>2003</risdate><volume>18</volume><issue>5</issue><spage>333</spage><epage>335</epage><pages>333-335</pages><issn>1347-4367</issn><eissn>1880-0920</eissn><abstract>We sequenced all exons and exon-intron junctions of the flavin-containing monooxygenase 3 (FMO3) gene from 27 Japanese individuals who are trimethylaminuria volunteers judged by self-reported analysis. We found two novel single nucleotide polymorphisms (SNPs) (21246T>Aand 21265C>T) causing amino acid substitutions (Asp198Glu and Arg205Cys in exon 5), respectively. The Asp198Glu allele also presented together with known SNPs (20852 C>T in exon4, 20960_20962 CTT deletion, 21115G>Ain intron 4, and 21243_21244 TG deletion in exon 5) in the same allele of the FMO3 gene to form a novel haplotype.
These sequences are as follows:1)SNP, 030609Fujieda019; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5′-TTCGGGCTG(TG/-)AT/AATTGCCACAGAA-3′.2)SNP, 030609Fujieda020; GENE NAME, FMO3; ACCESSION NUMBER, AL021026; LENGTH, 25 base; 5′-ACAGAACTCAGCC/TGCACAGCAGAAC-3′.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15618753</pmid><doi>10.2133/dmpk.18.333</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1347-4367 |
| ispartof | DRUG METABOLISM AND PHARMACOKINETICS, 2003, Vol.18 (5), p.333-335 |
| issn | 1347-4367 1880-0920 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71594189 |
| source | J-STAGE Free; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | fish-odor syndrome Flavin-containing monooxygenase genetic polymorphism Japanese trimethylaminuria |
| title | Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T03%3A18%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Two%20Novel%20Single%20Nucleotide%20Polymorphisms%20(SNPs)%20of%20the%20FMO3%20Gene%20in%20Japanese&rft.jtitle=DRUG%20METABOLISM%20AND%20PHARMACOKINETICS&rft.au=Fujieda,%20Masaki&rft.aucorp=Laboratory%20of%20Drug%20Metabolism&rft.date=2003&rft.volume=18&rft.issue=5&rft.spage=333&rft.epage=335&rft.pages=333-335&rft.issn=1347-4367&rft.eissn=1880-0920&rft_id=info:doi/10.2133/dmpk.18.333&rft_dat=%3Cproquest_cross%3E71594189%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71594189&rft_id=info:pmid/15618753&rft_els_id=S1347436715309010&rfr_iscdi=true |