Heteroduplex-based genotyping with microchip electrophoresis and dHPLC

This work compares the methods of mutation detection via denaturing high-performance liquid chromatography (dHPLC) and a microchip-based heteroduplex analysis (HA) method. The mutations analyzed were 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 with, as additional examples, 188del11 and 5396...

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Veröffentlicht in:	Genetic testing 2003-12, Vol.7 (4), p.283-293
Hauptverfasser:	Footz, Tim, Somerville, Martin J, Tomaszewski, Robert, Sprysak, Kathleen A, Backhouse, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 Protein - genetics BRCA2 Protein - genetics Chromatography, High Pressure Liquid - methods DNA Mutational Analysis - methods Electrophoresis - methods Genotype Heteroduplex Analysis - methods Humans Oligonucleotide Array Sequence Analysis - methods Sensitivity and Specificity
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