The Stress Cascade and Schizophrenia: Etiology and Onset
Psychosocial stress is included in most etiologic models of schizophrenia, frequently as a precipitating factor for psychosis in vulnerable individuals. Nonetheless, the stress-diathesis model has not been tested prospectively in prodromal patients as a predictor of psychosis. The biological effects...
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| Veröffentlicht in: | Schizophrenia bulletin 2003-01, Vol.29 (4), p.671-692 |
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| container_title | Schizophrenia bulletin |
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| creator | Corcoran, Cheryl Walker, Elaine Huot, Rebecca Mittal, Vijay Tessner, Kevin Kestler, Lisa Malaspina, Dolores |
| description | Psychosocial stress is included in most etiologic models of schizophrenia, frequently as a precipitating factor for psychosis in vulnerable individuals. Nonetheless, the stress-diathesis model has not been tested prospectively in prodromal patients as a predictor of psychosis. The biological effects of stress are mediated by the hypothalamic-pituitary-adrenal (HPA) axis, which governs the release of steroids, including cortisol. The past few decades have witnessed an increased understanding of the neural effects of stress and cortisol, including both normal and abnormal diatheses. As few biological markers have been evaluated as risk factors for psychosis in prodromal patients, the HPA axis and its interaction with intervening life events are apt candidates for study. In this article, we review the HPA axis and its neural effects, present a model for how stress might precipitate psychosis in vulnerable individuals, review the empirical evidence of a link between stress and schizophrenia symptoms, and propose a research design and appropriate statistical models to test the stress-diathesis model for psychosis onset in prodromal patients. |
| doi_str_mv | 10.1093/oxfordjournals.schbul.a007038 |
| format | Article |
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In this article, we review the HPA axis and its neural effects, present a model for how stress might precipitate psychosis in vulnerable individuals, review the empirical evidence of a link between stress and schizophrenia symptoms, and propose a research design and appropriate statistical models to test the stress-diathesis model for psychosis onset in prodromal patients.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/oxfordjournals.schbul.a007038</identifier><identifier>PMID: 14989406</identifier><identifier>CODEN: SCZBB3</identifier><language>eng</language><publisher>Oxford: National Institute of Mental Health</publisher><subject>Adult and adolescent clinical studies ; Animals ; Biological and medical sciences ; Disease Course ; Disease Progression ; Etiology ; Human ; Humans ; Hydrocortisone ; Hydrocortisone - blood ; Hypothalamic Pituitary Adrenal Axis ; Hypothalamo-Hypophyseal System - physiopathology ; Medical sciences ; Neural Development ; Onset (Disorders) ; Pituitary-Adrenal System - physiopathology ; Psychology. 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Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychosis</subject><subject>Psychosocial Factors</subject><subject>Risk Factors</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - etiology</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Schizotypal Personality Disorder - diagnosis</subject><subject>Schizotypal Personality Disorder - etiology</subject><subject>Schizotypal Personality Disorder - physiopathology</subject><subject>Stress</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - physiopathology</subject><subject>Susceptibility (Disorders)</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c1u1DAUBWALUdGh8AooQioblKkd23GMxAKNClSq1EVnb904N0yqTBx8E4np0-NhgipYdOWFv-ufcxi7FHwtuJVX4VcbYvMQ5jhAT2vyu3ru18C54bJ6wVbCKJ0Lw8VLtuK6KnNTCnXOXhM9cC6ULYtX7DytlVW8XLFqu8PsfopIlG2APDSYwdBk937XPYZxF3Ho4FN2PXWhDz8Of_buBsLpDTtr0wPw7bJesO3X6-3me3579-1m8-U2B10WU65thVUhlZCoVCVUKxBEIY0ytdelbNFz0dZQV94abKTUUAMapXhjraxbecE-nI4dY_g5I01u35HHvocBw0zOCG3Tb3WC7_-DfzNyKQCltC35c6gopFaJHNHnE_IxEEVs3Ri7PcSDE9wdO3D_duBOHbilgzT_brlkrvfYPE0voSdwuYBj4H0bYfAdPTmtjZHcJPfx5GAEN9LBQ5w63yP5OaZeJkePtSusU640Qv4Ga3SlAw</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Corcoran, Cheryl</creator><creator>Walker, Elaine</creator><creator>Huot, Rebecca</creator><creator>Mittal, Vijay</creator><creator>Tessner, Kevin</creator><creator>Kestler, Lisa</creator><creator>Malaspina, Dolores</creator><general>National Institute of Mental Health</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>The Stress Cascade and Schizophrenia: Etiology and Onset</title><author>Corcoran, Cheryl ; Walker, Elaine ; Huot, Rebecca ; Mittal, Vijay ; Tessner, Kevin ; Kestler, Lisa ; Malaspina, Dolores</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a562t-598e823413e44814f1ea123747bc563fec01fbab8c97ed335abae7440d993bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Course</topic><topic>Disease Progression</topic><topic>Etiology</topic><topic>Human</topic><topic>Humans</topic><topic>Hydrocortisone</topic><topic>Hydrocortisone - blood</topic><topic>Hypothalamic Pituitary Adrenal Axis</topic><topic>Hypothalamo-Hypophyseal System - physiopathology</topic><topic>Medical sciences</topic><topic>Neural Development</topic><topic>Onset (Disorders)</topic><topic>Pituitary-Adrenal System - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychosis</topic><topic>Psychosocial Factors</topic><topic>Risk Factors</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - etiology</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Schizotypal Personality Disorder - diagnosis</topic><topic>Schizotypal Personality Disorder - etiology</topic><topic>Schizotypal Personality Disorder - physiopathology</topic><topic>Stress</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - physiopathology</topic><topic>Susceptibility (Disorders)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corcoran, Cheryl</creatorcontrib><creatorcontrib>Walker, Elaine</creatorcontrib><creatorcontrib>Huot, Rebecca</creatorcontrib><creatorcontrib>Mittal, Vijay</creatorcontrib><creatorcontrib>Tessner, Kevin</creatorcontrib><creatorcontrib>Kestler, Lisa</creatorcontrib><creatorcontrib>Malaspina, Dolores</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corcoran, Cheryl</au><au>Walker, Elaine</au><au>Huot, Rebecca</au><au>Mittal, Vijay</au><au>Tessner, Kevin</au><au>Kestler, Lisa</au><au>Malaspina, Dolores</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Stress Cascade and Schizophrenia: Etiology and Onset</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>29</volume><issue>4</issue><spage>671</spage><epage>692</epage><pages>671-692</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><coden>SCZBB3</coden><abstract>Psychosocial stress is included in most etiologic models of schizophrenia, frequently as a precipitating factor for psychosis in vulnerable individuals. 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| subjects | Adult and adolescent clinical studies Animals Biological and medical sciences Disease Course Disease Progression Etiology Human Humans Hydrocortisone Hydrocortisone - blood Hypothalamic Pituitary Adrenal Axis Hypothalamo-Hypophyseal System - physiopathology Medical sciences Neural Development Onset (Disorders) Pituitary-Adrenal System - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychosis Psychosocial Factors Risk Factors Schizophrenia Schizophrenia - diagnosis Schizophrenia - etiology Schizophrenia - physiopathology Schizophrenic Psychology Schizotypal Personality Disorder - diagnosis Schizotypal Personality Disorder - etiology Schizotypal Personality Disorder - physiopathology Stress Stress, Psychological - complications Stress, Psychological - physiopathology Susceptibility (Disorders) |
| title | The Stress Cascade and Schizophrenia: Etiology and Onset |
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