Retroinfusion of NFkappaB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs

Myocardial reperfusion injury is partially mediated by postischemic inflammation. Beyond acute PMN recruitment, postischemic inflammation comprises subacute PMN adhesion, eg via NFkappaB activation. In a pig model of 60-min LAD occlusion by PTCA ballon inflation and 1 to 7 days of reperfusion, we in...

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Veröffentlicht in:	Gene therapy 2002-04, Vol.9 (8), p.518-526
Hauptverfasser:	Kupatt, C, Wichels, R, Deiss, M, Molnar, A, Lebherz, C, Raake, P, von Degenfeld, G, Hahnel, D, Boekstegers, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antibodies, Monoclonal - administration & dosage Apoptosis CD18 Antigens - immunology Coronary Vessels Endothelium, Vascular - metabolism Genetic Therapy - methods Liposomes Models, Animal Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - therapy Myocardium - metabolism NF-kappa B - genetics Oligonucleotides - administration & dosage Rats Swine Transfection - methods
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