AG-041R, a cholecystokinin-B/gastrin receptor antagonist, stimulates the repair of osteochondral defect in rabbit model

A newly synthesized compound (AG-041R), 3R-1-(2,2Diethoxyethyl)-((4methylphenyl) amino-carbonyl methyl)-3-((4methylphenyl) ureido-indoline-2-one), is a cholecystokinin-B/gastrin receptor antagonist which has stimulatory effects on the matrix synthesis of chondrocytes in vitro. In this study, we exam...

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Veröffentlicht in:	European journal of pharmacology 2002-03, Vol.439 (1), p.135-140
Hauptverfasser:	Nakanishi, Toru, Kawasaki, Kenzo, Uchio, Yuji, Kataoka, Hiroko, Terashima, Masaharu, Ochi, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Articular cartilage Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cartilage, Articular - drug effects Cartilage, Articular - injuries Cartilage, Articular - physiopathology Cholecystokinin-B/gastrin receptor antagonist Chondrocyte Chondroitin Sulfates - metabolism Glycosaminoglycans - metabolism Indoles - pharmacology Knee Joint - drug effects Knee Joint - metabolism Knee Joint - physiopathology Male Medical sciences Models, Animal Osteochondral defect Pharmacology. Drug treatments Rabbit Rabbits Receptors, Cholecystokinin - antagonists & inhibitors Repair Wound Healing - drug effects
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