Dissecting planarian central nervous system regeneration by the expression of neural‐specific genes
The planarian central nervous system (CNS) can be used as a model for studying neural regeneration in higher organisms. Despite its simple structure, recent studies have shown that the planarian CNS can be divided into several molecular and functional domains defined by the expression of different n...
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| Veröffentlicht in: | Development, growth & differentiation growth & differentiation, 2002-04, Vol.44 (2), p.135-146 |
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| creator | Cebrià, Francesc Nakazawa, Masumi Mineta, Katsuhiko Ikeo, Kazuho Gojobori, Takashi Agata, Kiyokazu |
| description | The planarian central nervous system (CNS) can be used as a model for studying neural regeneration in higher organisms. Despite its simple structure, recent studies have shown that the planarian CNS can be divided into several molecular and functional domains defined by the expression of different neural genes. Remarkably, a whole animal, including the molecularly complex CNS, can regenerate from a small piece of the planarian body. In this study, a collection of neural markers has been used to characterize at the molecular level how the planarian CNS is rebuilt. Planarian CNS is composed of an anterior brain and a pair of ventral nerve cords that are distinct and overlapping structures in the head region. During regeneration, 12 neural markers have been classified as early, mid‐regeneration and late expression genes depending on when they are upregulated in the regenerative blastema. Interestingly, the results from this study show that the comparison of the expression patterns of different neural genes supports the view that at day one of regeneration, the new brain appears within the blastema, whereas the pre‐existing ventral nerve cords remain in the old tissues. Three stages in planarian CNS regeneration are suggested. |
| doi_str_mv | 10.1046/j.1440-169x.2002.00629.x |
| format | Article |
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Despite its simple structure, recent studies have shown that the planarian CNS can be divided into several molecular and functional domains defined by the expression of different neural genes. Remarkably, a whole animal, including the molecularly complex CNS, can regenerate from a small piece of the planarian body. In this study, a collection of neural markers has been used to characterize at the molecular level how the planarian CNS is rebuilt. Planarian CNS is composed of an anterior brain and a pair of ventral nerve cords that are distinct and overlapping structures in the head region. During regeneration, 12 neural markers have been classified as early, mid‐regeneration and late expression genes depending on when they are upregulated in the regenerative blastema. 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Ltd</publisher><subject>Amino Acid Sequence ; Animals ; brain ; Brain - growth & development ; Brain - metabolism ; central nervous system (CNS) ; Central Nervous System - growth & development ; Central Nervous System - physiology ; Gene Expression Regulation, Developmental ; Immunoassay ; In Situ Hybridization ; Models, Biological ; Molecular Sequence Data ; Nerve Growth Factors - genetics ; Nerve Growth Factors - metabolism ; Nerve Regeneration - physiology ; netrin ; Netrin-1 ; planarian ; Planarians - growth & development ; Planarians - physiology ; regeneration ; Sequence Homology, Amino Acid ; Tumor Suppressor Proteins</subject><ispartof>Development, growth & differentiation, 2002-04, Vol.44 (2), p.135-146</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5369-89f49f1bfd11eae95fab79569ee281b41a030e256780c1f031a2cd9d13afbb983</citedby><cites>FETCH-LOGICAL-c5369-89f49f1bfd11eae95fab79569ee281b41a030e256780c1f031a2cd9d13afbb983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-169x.2002.00629.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-169x.2002.00629.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11940100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cebrià, Francesc</creatorcontrib><creatorcontrib>Nakazawa, Masumi</creatorcontrib><creatorcontrib>Mineta, Katsuhiko</creatorcontrib><creatorcontrib>Ikeo, Kazuho</creatorcontrib><creatorcontrib>Gojobori, Takashi</creatorcontrib><creatorcontrib>Agata, Kiyokazu</creatorcontrib><title>Dissecting planarian central nervous system regeneration by the expression of neural‐specific genes</title><title>Development, growth & differentiation</title><addtitle>Dev Growth Differ</addtitle><description>The planarian central nervous system (CNS) can be used as a model for studying neural regeneration in higher organisms. Despite its simple structure, recent studies have shown that the planarian CNS can be divided into several molecular and functional domains defined by the expression of different neural genes. Remarkably, a whole animal, including the molecularly complex CNS, can regenerate from a small piece of the planarian body. In this study, a collection of neural markers has been used to characterize at the molecular level how the planarian CNS is rebuilt. Planarian CNS is composed of an anterior brain and a pair of ventral nerve cords that are distinct and overlapping structures in the head region. During regeneration, 12 neural markers have been classified as early, mid‐regeneration and late expression genes depending on when they are upregulated in the regenerative blastema. Interestingly, the results from this study show that the comparison of the expression patterns of different neural genes supports the view that at day one of regeneration, the new brain appears within the blastema, whereas the pre‐existing ventral nerve cords remain in the old tissues. Three stages in planarian CNS regeneration are suggested.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>brain</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>central nervous system (CNS)</subject><subject>Central Nervous System - growth & development</subject><subject>Central Nervous System - physiology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Immunoassay</subject><subject>In Situ Hybridization</subject><subject>Models, Biological</subject><subject>Molecular Sequence Data</subject><subject>Nerve Growth Factors - genetics</subject><subject>Nerve Growth Factors - metabolism</subject><subject>Nerve Regeneration - physiology</subject><subject>netrin</subject><subject>Netrin-1</subject><subject>planarian</subject><subject>Planarians - growth & development</subject><subject>Planarians - physiology</subject><subject>regeneration</subject><subject>Sequence Homology, Amino Acid</subject><subject>Tumor Suppressor Proteins</subject><issn>0012-1592</issn><issn>1440-169X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkbFu2zAQhomiQeOkfYWCUzYpdxQli0CXIG6TAAa6pEA3gqKPKQ1ZUkm5sbc-Qp6xTxIqdtGxmUgcv--Iu58xjpAjyOpynaOUkGGldrkAEDlAJVS-e8Nmfx--v2UzABQZlkqcsrMY1wAgJYp37BRRSUCAGaOFj5Hs6LsHPrSmM8GbjlvqxmBa3lH41W8jj_s40oYHeqBUMqPvO97s-fiDOO2GQDFOld4lYZu8P7-f4kDWO2_5ZMT37MSZNtKH43nOvn35fH99my2_3txdXy0zWxaVymrlpHLYuBUiGVKlM81clZUiEjU2Eg0UQKKs5jVYdFCgEXalVlgY1zSqLs7ZxaHvEPqfW4qj3vhoqU2DUZpDz7GsK1Wq_4JYS1nWKBJYH0Ab-hgDOT0EvzFhrxH0lIVe62nlespCT1nolyz0Lqkfj39smw2t_onH5Sfg0wF49C3tX91YL24W6VI8A5j_m2g</recordid><startdate>200204</startdate><enddate>200204</enddate><creator>Cebrià, Francesc</creator><creator>Nakazawa, Masumi</creator><creator>Mineta, Katsuhiko</creator><creator>Ikeo, Kazuho</creator><creator>Gojobori, Takashi</creator><creator>Agata, Kiyokazu</creator><general>Blackwell Science Asia Pty. 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Despite its simple structure, recent studies have shown that the planarian CNS can be divided into several molecular and functional domains defined by the expression of different neural genes. Remarkably, a whole animal, including the molecularly complex CNS, can regenerate from a small piece of the planarian body. In this study, a collection of neural markers has been used to characterize at the molecular level how the planarian CNS is rebuilt. Planarian CNS is composed of an anterior brain and a pair of ventral nerve cords that are distinct and overlapping structures in the head region. During regeneration, 12 neural markers have been classified as early, mid‐regeneration and late expression genes depending on when they are upregulated in the regenerative blastema. 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| subjects | Amino Acid Sequence Animals brain Brain - growth & development Brain - metabolism central nervous system (CNS) Central Nervous System - growth & development Central Nervous System - physiology Gene Expression Regulation, Developmental Immunoassay In Situ Hybridization Models, Biological Molecular Sequence Data Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Nerve Regeneration - physiology netrin Netrin-1 planarian Planarians - growth & development Planarians - physiology regeneration Sequence Homology, Amino Acid Tumor Suppressor Proteins |
| title | Dissecting planarian central nervous system regeneration by the expression of neural‐specific genes |
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