De Novo Central Nervous System Processing of Myelin Antigen Is Required for the Initiation of Experimental Autoimmune Encephalomyelitis

We demonstrate the absolute requirement for a functioning class II-restricted Ag processing pathway in the CNS for the initiation of experimental autoimmune encephalomyelitis (EAE). C57BL/6 (B6) mice deficient for the class II transactivator, which have defects in MHC class II, invariant chain (Ii),...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2002-04, Vol.168 (8), p.4173-4183
Hauptverfasser:	Tompkins, Stephen Mark, Padilla, Josette, Dal Canto, Mauro C, Ting, Jenny P.-Y, Van Kaer, Luc, Miller, Stephen D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Amino Acid Sequence Animals Antigen Presentation - genetics Antigens, Differentiation, B-Lymphocyte - genetics Cell Movement - genetics Cell Movement - immunology Central Nervous System - immunology Central Nervous System - metabolism Central Nervous System - pathology Encephalomyelitis, Autoimmune, Experimental - etiology Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Epitopes, T-Lymphocyte - administration & dosage Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Female Glycoproteins - administration & dosage Glycoproteins - immunology Glycoproteins - metabolism Histocompatibility Antigens Class II - genetics Immunity, Innate - genetics Injections, Subcutaneous Lymphocyte Activation - genetics Male Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Myelin Proteolipid Protein - administration & dosage Myelin Proteolipid Protein - immunology Myelin Proteolipid Protein - metabolism Myelin-Oligodendrocyte Glycoprotein Nuclear Proteins Peptide Fragments - administration & dosage Peptide Fragments - immunology Peptide Fragments - metabolism Th1 Cells - immunology Th1 Cells - metabolism Trans-Activators - deficiency Trans-Activators - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!