Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor

Using a 'directed' iodination procedure, novel iodo-resiniferatoxin congeners were synthesized from 4-acetoxy-3-methoxyphenylacetic acid and resiniferinol- 9,13,14-ortho-phenylacetate (ROPA). The 2-iodo-4-hydroxy-5-methoxyphenylacetic acid ester of resiniferinol 5 displayed high affinity b...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-04, Vol.12 (8), p.1189-1192
Hauptverfasser:	MCDONNELL, Mark E, ZHANG, Sui-Po, DUBIN, Adrienne E, DAX, Scott L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology Drug Evaluation, Preclinical Humans In Vitro Techniques Iodine - chemistry Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Receptors, Drug - agonists
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!