Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains
Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase synthesis of these potent inhibitors of procollagen C-proteinase (PCP) is presented. In addition, novel carboxylic acid sulfonamides were di...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2002-04, Vol.12 (8), p.1233-1235 |
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| container_end_page | 1235 |
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| container_issue | 8 |
| container_start_page | 1233 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 12 |
| creator | DANKWARDT, Sharon M ABBOT, Sarah C BROKA, Chris A MARTIN, Robert L CHAN, Christine S SPRINGMAN, Eric B VAN WART, Harold E WALKER, Keith A. M |
| description | Optimization of the amino acid side chain and the N-alkyl group of the sulfonamide of amino acid derived sulfonamide hydroxamates is discussed. The solid-phase synthesis of these potent inhibitors of procollagen C-proteinase (PCP) is presented. In addition, novel carboxylic acid sulfonamides were discovered to be PCP inhibitors. |
| doi_str_mv | 10.1016/S0960-894X(02)00117-8 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2002-04, Vol.12 (8), p.1233-1235 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acids - chemistry Biological and medical sciences Bone Morphogenetic Protein 1 Bone Morphogenetic Proteins - antagonists & inhibitors Bones, joints and connective tissue. Antiinflammatory agents Hydroxamic Acids - chemical synthesis Hydroxamic Acids - chemistry Hydroxamic Acids - pharmacology Medical sciences Metalloendopeptidases - antagonists & inhibitors Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Structure-Activity Relationship Sulfonamides - chemistry |
| title | Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains |
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