Effect of Sarcostemma acidum stem extract on spermatogenesis in male albino rats
To evaluate the possible antifertility activity of Sarcostemma acidum (Roxb) Voigt. stem extract in male rats. Male rats were given 70% methanol extract of S. acidum stem orally at dose levels of 50 and 100 mg/kg/day for 60 days. Fertility was evaluated with mating test. Sperm motility and sperm den...
Gespeichert in:
| Veröffentlicht in: | Asian journal of andrology 2002-03, Vol.4 (1), p.43-47 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 47 |
|---|---|
| container_issue | 1 |
| container_start_page | 43 |
| container_title | Asian journal of andrology |
| container_volume | 4 |
| creator | PRAMOD KUMAR VERMA SHARMA, Anita MATHUR, Annu SHARMA, Prachi GUPTA, R. S JOSHI, S. C DIXIT, V. P |
| description | To evaluate the possible antifertility activity of Sarcostemma acidum (Roxb) Voigt. stem extract in male rats.
Male rats were given 70% methanol extract of S. acidum stem orally at dose levels of 50 and 100 mg/kg/day for 60 days. Fertility was evaluated with mating test. Sperm motility and sperm density in cauda epididymides were also assessed. Biochemical and histological analyses were performed on blood samples and on the reproductive organs.
S. acidum stem extract resulted in an arrest of spermatogenesis without any systemic side effect. Sperm motility as well as sperm density was reduced significantly. Treatment caused a 80% reduction in fertility at the 50 mg dose and complete suppression of fertility at the 100 mg dose. There was no significant change in RBC and WBC count, hemoglobin, haematocrit, sugar and urea in the whole blood and cholesterol, protein and phospholipid in the serum. The protein and glycogen content of the testes, fructose in the seminal vesicle and protein in epididymides were significantly decreased. Cholesterol in the testes was elevated. Treatment at both of the doses caused a marked reduction in the number of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and spermatids. The number of mature Leydig cells was decreased, and degenerating Leydig cells was increased proportionately.
S. acidum stem extract arrests spermatogenesis in male rats without noticable side effects. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_71582209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>6647112</cqvip_id><sourcerecordid>71582209</sourcerecordid><originalsourceid>FETCH-LOGICAL-c263t-6123a005eecf206a9c3e556c53f76a07b0160967c958e38e4cdb28e8c88b92223</originalsourceid><addsrcrecordid>eNpF0E1LAzEQBuBFFFurf0HiQW8LSbb5OkqpH1BQUMHbMptOanSTbZMt6L93Syue5h14eGHmqBgzNRWl4pIfD5lSXUrN30fFWc6flPKKGXNajBgzVEmuxsXz3Dm0PekceYFku9xjCEDA-uU2kN1G8LtPsCOR5DWmAH23wojZZ-IjCdAigbbxsSMJ-nxenDhoM14c5qR4u5u_zh7KxdP94-x2UVouq76UjFdAqUC0jlMJxlYohLSickoCVQ1lkhqprBEaK41Tu2y4Rm21bgznvJoUN_vedeo2W8x9HXy22LYQsdvmWjGhOadmgJcHuG0CLut18gHST_33gwFcHwBkC61LEK3P_64SgiqzK7raO_vRxdXGx1XdgP1yvsVayqliw0m_9nFwww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71582209</pqid></control><display><type>article</type><title>Effect of Sarcostemma acidum stem extract on spermatogenesis in male albino rats</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><creator>PRAMOD KUMAR VERMA ; SHARMA, Anita ; MATHUR, Annu ; SHARMA, Prachi ; GUPTA, R. S ; JOSHI, S. C ; DIXIT, V. P</creator><creatorcontrib>PRAMOD KUMAR VERMA ; SHARMA, Anita ; MATHUR, Annu ; SHARMA, Prachi ; GUPTA, R. S ; JOSHI, S. C ; DIXIT, V. P</creatorcontrib><description>To evaluate the possible antifertility activity of Sarcostemma acidum (Roxb) Voigt. stem extract in male rats.
Male rats were given 70% methanol extract of S. acidum stem orally at dose levels of 50 and 100 mg/kg/day for 60 days. Fertility was evaluated with mating test. Sperm motility and sperm density in cauda epididymides were also assessed. Biochemical and histological analyses were performed on blood samples and on the reproductive organs.
S. acidum stem extract resulted in an arrest of spermatogenesis without any systemic side effect. Sperm motility as well as sperm density was reduced significantly. Treatment caused a 80% reduction in fertility at the 50 mg dose and complete suppression of fertility at the 100 mg dose. There was no significant change in RBC and WBC count, hemoglobin, haematocrit, sugar and urea in the whole blood and cholesterol, protein and phospholipid in the serum. The protein and glycogen content of the testes, fructose in the seminal vesicle and protein in epididymides were significantly decreased. Cholesterol in the testes was elevated. Treatment at both of the doses caused a marked reduction in the number of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and spermatids. The number of mature Leydig cells was decreased, and degenerating Leydig cells was increased proportionately.
S. acidum stem extract arrests spermatogenesis in male rats without noticable side effects.</description><identifier>ISSN: 1008-682X</identifier><identifier>EISSN: 1745-7262</identifier><identifier>PMID: 11907627</identifier><language>eng</language><publisher>Oxford: blackwell</publisher><subject>Animals ; Associated diseases and complications ; Biological and medical sciences ; Blood Cell Count ; Body Weight - drug effects ; Cholesterol - metabolism ; Contraceptive Agents, Male - pharmacology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Glycogen - metabolism ; Hormones. Endocrine system ; Leydig Cells - drug effects ; Leydig Cells - metabolism ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Phospholipids - blood ; Plant Extracts - pharmacology ; Plants, Medicinal ; Rats ; Rats, Sprague-Dawley ; Spermatids - drug effects ; Spermatocytes - drug effects ; Spermatogenesis - drug effects ; 白化病 ; 精子发生 ; 肉珊瑚 ; 莱迪希细胞 ; 雄激素</subject><ispartof>Asian journal of andrology, 2002-03, Vol.4 (1), p.43-47</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84127X/84127X.jpg</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13550799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11907627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PRAMOD KUMAR VERMA</creatorcontrib><creatorcontrib>SHARMA, Anita</creatorcontrib><creatorcontrib>MATHUR, Annu</creatorcontrib><creatorcontrib>SHARMA, Prachi</creatorcontrib><creatorcontrib>GUPTA, R. S</creatorcontrib><creatorcontrib>JOSHI, S. C</creatorcontrib><creatorcontrib>DIXIT, V. P</creatorcontrib><title>Effect of Sarcostemma acidum stem extract on spermatogenesis in male albino rats</title><title>Asian journal of andrology</title><addtitle>Asian Journal of Andrology</addtitle><description>To evaluate the possible antifertility activity of Sarcostemma acidum (Roxb) Voigt. stem extract in male rats.
Male rats were given 70% methanol extract of S. acidum stem orally at dose levels of 50 and 100 mg/kg/day for 60 days. Fertility was evaluated with mating test. Sperm motility and sperm density in cauda epididymides were also assessed. Biochemical and histological analyses were performed on blood samples and on the reproductive organs.
S. acidum stem extract resulted in an arrest of spermatogenesis without any systemic side effect. Sperm motility as well as sperm density was reduced significantly. Treatment caused a 80% reduction in fertility at the 50 mg dose and complete suppression of fertility at the 100 mg dose. There was no significant change in RBC and WBC count, hemoglobin, haematocrit, sugar and urea in the whole blood and cholesterol, protein and phospholipid in the serum. The protein and glycogen content of the testes, fructose in the seminal vesicle and protein in epididymides were significantly decreased. Cholesterol in the testes was elevated. Treatment at both of the doses caused a marked reduction in the number of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and spermatids. The number of mature Leydig cells was decreased, and degenerating Leydig cells was increased proportionately.
S. acidum stem extract arrests spermatogenesis in male rats without noticable side effects.</description><subject>Animals</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count</subject><subject>Body Weight - drug effects</subject><subject>Cholesterol - metabolism</subject><subject>Contraceptive Agents, Male - pharmacology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Glycogen - metabolism</subject><subject>Hormones. Endocrine system</subject><subject>Leydig Cells - drug effects</subject><subject>Leydig Cells - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phospholipids - blood</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spermatids - drug effects</subject><subject>Spermatocytes - drug effects</subject><subject>Spermatogenesis - drug effects</subject><subject>白化病</subject><subject>精子发生</subject><subject>肉珊瑚</subject><subject>莱迪希细胞</subject><subject>雄激素</subject><issn>1008-682X</issn><issn>1745-7262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LAzEQBuBFFFurf0HiQW8LSbb5OkqpH1BQUMHbMptOanSTbZMt6L93Syue5h14eGHmqBgzNRWl4pIfD5lSXUrN30fFWc6flPKKGXNajBgzVEmuxsXz3Dm0PekceYFku9xjCEDA-uU2kN1G8LtPsCOR5DWmAH23wojZZ-IjCdAigbbxsSMJ-nxenDhoM14c5qR4u5u_zh7KxdP94-x2UVouq76UjFdAqUC0jlMJxlYohLSickoCVQ1lkhqprBEaK41Tu2y4Rm21bgznvJoUN_vedeo2W8x9HXy22LYQsdvmWjGhOadmgJcHuG0CLut18gHST_33gwFcHwBkC61LEK3P_64SgiqzK7raO_vRxdXGx1XdgP1yvsVayqliw0m_9nFwww</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>PRAMOD KUMAR VERMA</creator><creator>SHARMA, Anita</creator><creator>MATHUR, Annu</creator><creator>SHARMA, Prachi</creator><creator>GUPTA, R. S</creator><creator>JOSHI, S. C</creator><creator>DIXIT, V. P</creator><general>blackwell</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Effect of Sarcostemma acidum stem extract on spermatogenesis in male albino rats</title><author>PRAMOD KUMAR VERMA ; SHARMA, Anita ; MATHUR, Annu ; SHARMA, Prachi ; GUPTA, R. S ; JOSHI, S. C ; DIXIT, V. P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c263t-6123a005eecf206a9c3e556c53f76a07b0160967c958e38e4cdb28e8c88b92223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood Cell Count</topic><topic>Body Weight - drug effects</topic><topic>Cholesterol - metabolism</topic><topic>Contraceptive Agents, Male - pharmacology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Glycogen - metabolism</topic><topic>Hormones. Endocrine system</topic><topic>Leydig Cells - drug effects</topic><topic>Leydig Cells - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phospholipids - blood</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spermatids - drug effects</topic><topic>Spermatocytes - drug effects</topic><topic>Spermatogenesis - drug effects</topic><topic>白化病</topic><topic>精子发生</topic><topic>肉珊瑚</topic><topic>莱迪希细胞</topic><topic>雄激素</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PRAMOD KUMAR VERMA</creatorcontrib><creatorcontrib>SHARMA, Anita</creatorcontrib><creatorcontrib>MATHUR, Annu</creatorcontrib><creatorcontrib>SHARMA, Prachi</creatorcontrib><creatorcontrib>GUPTA, R. S</creatorcontrib><creatorcontrib>JOSHI, S. C</creatorcontrib><creatorcontrib>DIXIT, V. P</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Asian journal of andrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PRAMOD KUMAR VERMA</au><au>SHARMA, Anita</au><au>MATHUR, Annu</au><au>SHARMA, Prachi</au><au>GUPTA, R. S</au><au>JOSHI, S. C</au><au>DIXIT, V. P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Sarcostemma acidum stem extract on spermatogenesis in male albino rats</atitle><jtitle>Asian journal of andrology</jtitle><addtitle>Asian Journal of Andrology</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>4</volume><issue>1</issue><spage>43</spage><epage>47</epage><pages>43-47</pages><issn>1008-682X</issn><eissn>1745-7262</eissn><abstract>To evaluate the possible antifertility activity of Sarcostemma acidum (Roxb) Voigt. stem extract in male rats.
Male rats were given 70% methanol extract of S. acidum stem orally at dose levels of 50 and 100 mg/kg/day for 60 days. Fertility was evaluated with mating test. Sperm motility and sperm density in cauda epididymides were also assessed. Biochemical and histological analyses were performed on blood samples and on the reproductive organs.
S. acidum stem extract resulted in an arrest of spermatogenesis without any systemic side effect. Sperm motility as well as sperm density was reduced significantly. Treatment caused a 80% reduction in fertility at the 50 mg dose and complete suppression of fertility at the 100 mg dose. There was no significant change in RBC and WBC count, hemoglobin, haematocrit, sugar and urea in the whole blood and cholesterol, protein and phospholipid in the serum. The protein and glycogen content of the testes, fructose in the seminal vesicle and protein in epididymides were significantly decreased. Cholesterol in the testes was elevated. Treatment at both of the doses caused a marked reduction in the number of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and spermatids. The number of mature Leydig cells was decreased, and degenerating Leydig cells was increased proportionately.
S. acidum stem extract arrests spermatogenesis in male rats without noticable side effects.</abstract><cop>Oxford</cop><pub>blackwell</pub><pmid>11907627</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1008-682X |
| ispartof | Asian journal of andrology, 2002-03, Vol.4 (1), p.43-47 |
| issn | 1008-682X 1745-7262 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71582209 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
| subjects | Animals Associated diseases and complications Biological and medical sciences Blood Cell Count Body Weight - drug effects Cholesterol - metabolism Contraceptive Agents, Male - pharmacology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Glycogen - metabolism Hormones. Endocrine system Leydig Cells - drug effects Leydig Cells - metabolism Male Medical sciences Pharmacology. Drug treatments Phospholipids - blood Plant Extracts - pharmacology Plants, Medicinal Rats Rats, Sprague-Dawley Spermatids - drug effects Spermatocytes - drug effects Spermatogenesis - drug effects 白化病 精子发生 肉珊瑚 莱迪希细胞 雄激素 |
| title | Effect of Sarcostemma acidum stem extract on spermatogenesis in male albino rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T06%3A04%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Sarcostemma%20acidum%20stem%20extract%20on%20spermatogenesis%20in%20male%20albino%20rats&rft.jtitle=Asian%20journal%20of%20andrology&rft.au=PRAMOD%20KUMAR%20VERMA&rft.date=2002-03-01&rft.volume=4&rft.issue=1&rft.spage=43&rft.epage=47&rft.pages=43-47&rft.issn=1008-682X&rft.eissn=1745-7262&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E71582209%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71582209&rft_id=info:pmid/11907627&rft_cqvip_id=6647112&rfr_iscdi=true |