Agonist–antagonist induced coactivator and corepressor interplay on the human androgen receptor

The human androgen receptor (AR) is a member of the nuclear hormone receptor superfamily. However, in contrast to other members of this family the amino-(N)-terminus of AR harbors the major transactivation function. Previously we have shown that hormone antagonists that bind to the carboxy-terminal...

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Veröffentlicht in:	Molecular and cellular endocrinology 2003-12, Vol.213 (1), p.79-85
Hauptverfasser:	Dotzlaw, Helmut, Papaioannou, Maria, Moehren, Udo, Claessens, Frank, Baniahmad, Aria
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Receptor Antagonists Androgens Binding, Competitive Coactivators and corepressors on androgen receptor Cofactor recruitment Cyproterone Acetate - pharmacology DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Histone Acetyltransferases Humans Ligand Ligands Nuclear Receptor Co-Repressor 2 Nuclear Receptor Coactivator 1 Protein Binding - drug effects Protein Interaction Mapping Receptors, Androgen - metabolism Repressor Proteins - metabolism Repressor Proteins - physiology Trans-Activators - metabolism Trans-Activators - physiology Transcription Factors - metabolism Transcription Factors - physiology
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