Oestrogenic repression of human coagulation factor VII expression mediated through an oestrogen response element sequence motif in the promoter region

Reporter gene analysis of two regions of the human factor VII (FVII) gene promoter (residues –658 to –1 and –348 to –1, where +1 is the start site of translation) in the mammalian liver-derived cell line HepG2 showed reduced transcriptional activity in the presence of oestrogenic factors. This effec...

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Veröffentlicht in:	Human molecular genetics 2002-04, Vol.11 (7), p.723-731
Hauptverfasser:	Di Bitondo, Rosa, Hall, Adrian J., Peake, Ian R., Iacoviello, Licia, Winship, Peter R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Down-Regulation Estrogens - genetics Estrogens - metabolism Factor VII - genetics Fundamental and applied biological sciences. Psychology Gene expression Humans Molecular and cellular biology Molecular genetics Mutation Promoter Regions, Genetic Receptors, Estrogen - metabolism Response Elements Sequence Analysis, DNA Transcription Factors - metabolism
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